Title: Pituitary Adenylate Cyclase Activating Polypeptide in Animal Models of Neurodegenerative Disorders - Implications for Huntington and Parkinsons Diseases
VOLUME: 2 ISSUE: 4
Author(s):D. Reglodi, A. Tamas and A. Somogyvari-Vigh
Affiliation:Tulane University School of Medicine, Department of Medicine, 1430 Tulane Avenue SL-35, NewOrleans, LA 70112, USA.
Keywords:pacap, neurodegeneration, neuroprotection, parkinson, huntington
Abstract: The present study summarizes results obtained with PACAP treatment in models of neurodegenerative diseases. The data show that PACAP protected a significant number of neurons in quinolinic acid- and 6-hydoxydopamine-induced lesions, which correlated with the less severe behavioral symptoms. These effects may have clinical implications in Huntington and Parkinsons diseases.
