Pituitary Adenylate Cyclase Activating Polypeptide in Animal Models of Neurodegenerative Disorders - Implications for Huntington and Parkinsons Diseases

D., Reglodi; A., Tamas; A., Somogyvari-Vigh

Pituitary Adenylate Cyclase Activating Polypeptide in Animal Models of Neurodegenerative Disorders - Implications for Huntington and Parkinsons Diseases

Author(s): D. Reglodi, A. Tamas, A. Somogyvari-Vigh

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Journal Name: Letters in Drug Design & Discovery

Volume 2 , Issue 4 , 2005

DOI : 10.2174/1570180054038440

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Abstract:

The present study summarizes results obtained with PACAP treatment in models of neurodegenerative diseases. The data show that PACAP protected a significant number of neurons in quinolinic acid- and 6-hydoxydopamine-induced lesions, which correlated with the less severe behavioral symptoms. These effects may have clinical implications in Huntington and Parkinsons diseases.

Keywords: pacap, neurodegeneration, neuroprotection, parkinson, huntington

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Letters in Drug Design & Discovery

Title: Pituitary Adenylate Cyclase Activating Polypeptide in Animal Models of Neurodegenerative Disorders - Implications for Huntington and Parkinsons Diseases

VOLUME: 2 ISSUE: 4

Author(s):D. Reglodi, A. Tamas and A. Somogyvari-Vigh

Affiliation:Tulane University School of Medicine, Department of Medicine, 1430 Tulane Avenue SL-35, NewOrleans, LA 70112, USA.

Keywords:pacap, neurodegeneration, neuroprotection, parkinson, huntington

Abstract: The present study summarizes results obtained with PACAP treatment in models of neurodegenerative diseases. The data show that PACAP protected a significant number of neurons in quinolinic acid- and 6-hydoxydopamine-induced lesions, which correlated with the less severe behavioral symptoms. These effects may have clinical implications in Huntington and Parkinsons diseases.

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D. Reglodi, A. Tamas and A. Somogyvari-Vigh, “ Pituitary Adenylate Cyclase Activating Polypeptide in Animal Models of Neurodegenerative Disorders - Implications for Huntington and Parkinsons Diseases”, Letters in Drug Design & Discovery (2005) 2: 311. https://doi.org/10.2174/1570180054038440

DOI https://doi.org/10.2174/1570180054038440	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X

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VOLUME: 2
ISSUE: 4
Year: 2005

Page: [311 - 315]
Pages: 5
DOI: 10.2174/1570180054038440
Price: $65

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