Title: The Tumor Necrosis Factor-Derived TIP Peptide: A Potential Anti-Edema Drug
VOLUME: 4 ISSUE: 5
Author(s):Rudolf Lucas, Harald Hundsberger, Maren Pfluger, Bernhard Fischer, Denis Morel, Clemens Braun, Albrecht Wendel, Trinad Chakraborty, Wolfgang Schutt, Christoph Wiesner and Jurg Hamacher
Affiliation:Department of Medical and Pharmaceutical Biotechnology, University of Applied Sciences, Piaristengasse 1, 3500, Krems, Austria.
Keywords:TNF, Pulmonary edema, Sodium channels, Lectin, Peptide
Abstract: In view of the significant side-effects of existing substances as well as of supportive therapies for the treatment of pulmonary edema, there is a renewed search for novel drugs that increase the uptake of sodium in type II alveolar epithelial cells, a phenomenon which is crucial for lung liquid clearance. We describe here the discovery and characterization of a Tumor Necrosis Factor (TNF)-derived peptide mimicking the lectin-like domain of the cytokine as a potential novel anti-edema agent.
