Abstract
Severe asthma is a complex heterogeneous disease with substantial unmet clinical need. Understanding the immunopathogenesis is likely to provide insights into potential novel therapies. To date researchers have focussed primarily at a single scale for example genome, cell or whole organ physiology. In this review we shall summarise the current knowledge of the immunopathogenesis of severe asthma integrated across multiple scales to provide the insights into the structure function relationships required to begin to unravel the complexity of severe asthma.
Keywords: Asthma, eosinophils, mast cels, remodelling, phenotyping, physiology, immunopathogenesis, Lung, biomechanical, Epidermal growth, neutrophils, cytokines, Mesenchymal progenitors, fibrocytes, hyper-responsiveness, sub-phenotypes
Current Pharmaceutical Design
Title: Immunopathogenesis of Severe Asthma
Volume: 17 Issue: 7
Author(s): Christopher E. Brightling, Sumit Gupta, Fay Hollins, Amanda Sutcliffe and Yassine Amrani
Affiliation:
Keywords: Asthma, eosinophils, mast cels, remodelling, phenotyping, physiology, immunopathogenesis, Lung, biomechanical, Epidermal growth, neutrophils, cytokines, Mesenchymal progenitors, fibrocytes, hyper-responsiveness, sub-phenotypes
Abstract: Severe asthma is a complex heterogeneous disease with substantial unmet clinical need. Understanding the immunopathogenesis is likely to provide insights into potential novel therapies. To date researchers have focussed primarily at a single scale for example genome, cell or whole organ physiology. In this review we shall summarise the current knowledge of the immunopathogenesis of severe asthma integrated across multiple scales to provide the insights into the structure function relationships required to begin to unravel the complexity of severe asthma.
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Cite this article as:
E. Brightling Christopher, Gupta Sumit, Hollins Fay, Sutcliffe Amanda and Amrani Yassine, Immunopathogenesis of Severe Asthma, Current Pharmaceutical Design 2011; 17 (7) . https://dx.doi.org/10.2174/138161211795429028
DOI https://dx.doi.org/10.2174/138161211795429028 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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