Abstract
Obesity is considered one of the risk factors for metabolic disorders such as diabetes mellitus. There is increasing evidence that obesity and diabetes are under the control of numerous cytokines and hormones, such as adiponectin and leptin. In addition, a number of studies have revealed that the brain functions play a role in the development of obesity and diabetes mellitus. Histamine and its receptors are classical inflammatory mediators in peripheral tissues and also function in the brain. The results of physiological and pharmacological studies revealed that brain histamine and its receptors are involved in the regulation of obesity and diabetes mellitus. Leptin has been shown to regulate obesity and diabetes partially via brain histamine and its receptors. In this review, we focused on the roles of brain histamine and its receptors in regulating obesity and diabetes mellitus.
Keywords: Histamine, Obesity, Histamine H1 receptors, Histamine H3 receptors, Diabetes
Current Diabetes Reviews
Title: Neuronal Histamine and its Receptors in Obesity and Diabetes
Volume: 3 Issue: 3
Author(s): Takayuki Masaki and Hironobu Yoshimatsu
Affiliation:
Keywords: Histamine, Obesity, Histamine H1 receptors, Histamine H3 receptors, Diabetes
Abstract: Obesity is considered one of the risk factors for metabolic disorders such as diabetes mellitus. There is increasing evidence that obesity and diabetes are under the control of numerous cytokines and hormones, such as adiponectin and leptin. In addition, a number of studies have revealed that the brain functions play a role in the development of obesity and diabetes mellitus. Histamine and its receptors are classical inflammatory mediators in peripheral tissues and also function in the brain. The results of physiological and pharmacological studies revealed that brain histamine and its receptors are involved in the regulation of obesity and diabetes mellitus. Leptin has been shown to regulate obesity and diabetes partially via brain histamine and its receptors. In this review, we focused on the roles of brain histamine and its receptors in regulating obesity and diabetes mellitus.
Export Options
About this article
Cite this article as:
Takayuki Masaki and Hironobu Yoshimatsu , Neuronal Histamine and its Receptors in Obesity and Diabetes, Current Diabetes Reviews 2007; 3 (3) . https://dx.doi.org/10.2174/157339907781369002
DOI https://dx.doi.org/10.2174/157339907781369002 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
L-carnosine and its Derivatives as New Therapeutic Agents for the Prevention and Treatment of Vascular Complications of Diabetes
Current Medicinal Chemistry Telmisartan in the Management of Diabetic Nephropathy: A Contemporary View
Current Diabetes Reviews The Antioxidant Effects of Radix Astragali (Astragalus membranaceus and Related Species) in Protecting Tissues from Injury and Disease
Current Drug Targets Novel Immunotherapeutic Strategies for Invasive Fungal Disease
Current Drug Targets - Cardiovascular & Hematological Disorders Insulin Resistance in Brain and Possible Therapeutic Approaches
Current Vascular Pharmacology Amplified Crosstalk Between Estrogen Binding and GFR Signaling Mediated Pathways of ER Activation Drives Responses in Tumors Treated with Endocrine Disruptors
Recent Patents on Anti-Cancer Drug Discovery Clinical Utility of Biomarkers in Premature Atherosclerosis
Current Medicinal Chemistry Adenocarcinoma of the Appendix in Elderly: Diagnostic Dilemma
New Emirates Medical Journal Optical Coherence Tomography for Complete Management of Patients with Diabetic Retinopathy
Current Diabetes Reviews Altered Steroid Metabolism and Insulin Signaling in PCOS Endometria: Impact in Tissue Function
Current Pharmaceutical Design Cognition and State Anxiety are Regulated by Thyroid Hormone Signaling
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) The Neuro-Vascular Consequence of Diabetes: Foot Amputation and Evaluation of its Risk Factors and Health-Related Economic Impact
Current Vascular Pharmacology The Role of Serum Calprotectin as a New Marker in Abdominal Aortic Aneurysms – A Preliminary Report
Current Pharmaceutical Biotechnology Short- and Long-Term Survival of Nonsurgical Intensive Care Patients and its Relation to Diagnosis, Severity of Disease, Age and Comorbidities
Current Aging Science Promoting Adult Hippocampal Neurogenesis: A Novel Strategy for Antidepressant Drug Screening
Current Medicinal Chemistry Novel Coronavirus SARS-CoV-2 (COVID-19) and Pregnancy: A Hypothetical View
Endocrine, Metabolic & Immune Disorders - Drug Targets Cardioprotective Effects of Sour Cherry Seed Extract (SCSE) on the Hypercholesterolemic Rabbit Heart
Current Pharmaceutical Design Coronary Atherosclerosis and Acute Coronary Syndrome: New Insights from Angioscopic Viewpoints
Vascular Disease Prevention (Discontinued) Association Between Intra-Hospital Uncontrolled Glycemia and Health Outcomes in Patients with Diabetes: A Systematic Review of Observational Studies
Current Diabetes Reviews Rational Targeting of Peroxisome Proliferating Activated Receptor Subtypes
Current Medicinal Chemistry