Abstract
Peroxisome proliferator-activated receptor-γ (PPAR-γ) belongs to a family of ligand-activated nuclear receptor and transcription factors. The essential roles of PPAR-γ in controlling metabolic processes have been underscored by the successful use of PPAR-γ agonists thiazolidinediones to treat insulin resistance, a central feature of metabolic syndrome. PPAR-γ is also expressed in the vascular tissues including endothelial cells (ECs), smooth muscle cells (SMCs) and macrophages. Increasing evidence suggests that PPAR-γ is implicated both in the maintenance of vascular homeostasis and in the pathogenesis of a number of vascular conditions such as atherosclerosis, hypertension and restenosis. As an important regulator of vascular biology, PPAR-γ may represent a potential therapeutic target for these metabolic vascular disorders. This review will focus on the recent advances related to the biological functions of PPAR-γ in various vascular processes as well as the significances of the pharmacological activators/modulators of this metabolic nuclear receptor in vascular disorders.
Keywords: Peroxisome proliferator-activated receptor, thiazolidinediones, metabolic syndrome, cardiovascular risk, diabetes
Cardiovascular & Hematological Disorders-Drug Targets
Title: Peroxisome Proliferator-Activated Receptor-γ in Vascular Biology
Volume: 7 Issue: 2
Author(s): Jingjue Li and Nanping Wang
Affiliation:
Keywords: Peroxisome proliferator-activated receptor, thiazolidinediones, metabolic syndrome, cardiovascular risk, diabetes
Abstract: Peroxisome proliferator-activated receptor-γ (PPAR-γ) belongs to a family of ligand-activated nuclear receptor and transcription factors. The essential roles of PPAR-γ in controlling metabolic processes have been underscored by the successful use of PPAR-γ agonists thiazolidinediones to treat insulin resistance, a central feature of metabolic syndrome. PPAR-γ is also expressed in the vascular tissues including endothelial cells (ECs), smooth muscle cells (SMCs) and macrophages. Increasing evidence suggests that PPAR-γ is implicated both in the maintenance of vascular homeostasis and in the pathogenesis of a number of vascular conditions such as atherosclerosis, hypertension and restenosis. As an important regulator of vascular biology, PPAR-γ may represent a potential therapeutic target for these metabolic vascular disorders. This review will focus on the recent advances related to the biological functions of PPAR-γ in various vascular processes as well as the significances of the pharmacological activators/modulators of this metabolic nuclear receptor in vascular disorders.
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Cite this article as:
Li Jingjue and Wang Nanping, Peroxisome Proliferator-Activated Receptor-γ in Vascular Biology, Cardiovascular & Hematological Disorders-Drug Targets 2007; 7 (2) . https://dx.doi.org/10.2174/187152907780830932
DOI https://dx.doi.org/10.2174/187152907780830932 |
Print ISSN 1871-529X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4063 |
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