Abstract
Proteases play an essential role in modulating the turnover of extracellular matrix. Furthermore, they are involved in the processing of various proteins thus regulating fundamental cellular functions such as apoptosis, cells growth and activation, protein secretion and phagocytosis. At the tissue and organ levels, proteases influence mechanisms including cell migration and invasion, cellular interactions and signal transduction as well as tissue formation and stabilization. Proteases are classified based on their catalytic mechanisms into serin, aspartic, metallo, threonin and cysteine proteases and are localized extracellularly, at the cellular surface, in the cytoplasm of cells or within specific subcellular structures such as lysosomes. The present review focuses on the specific functions of lysosomal cysteine proteases and the potential effects of modulators of cysteine protease activity.
Keywords: Cysteine, protease, cathepsin, tumor, COPD, infection, allergy
Current Drug Targets
Title: Proteases and Their Role in Chronic Inflammatory Lung Diseases
Volume: 7 Issue: 6
Author(s): Frank Buhling, David Groneberg and Tobias Welte
Affiliation:
Keywords: Cysteine, protease, cathepsin, tumor, COPD, infection, allergy
Abstract: Proteases play an essential role in modulating the turnover of extracellular matrix. Furthermore, they are involved in the processing of various proteins thus regulating fundamental cellular functions such as apoptosis, cells growth and activation, protein secretion and phagocytosis. At the tissue and organ levels, proteases influence mechanisms including cell migration and invasion, cellular interactions and signal transduction as well as tissue formation and stabilization. Proteases are classified based on their catalytic mechanisms into serin, aspartic, metallo, threonin and cysteine proteases and are localized extracellularly, at the cellular surface, in the cytoplasm of cells or within specific subcellular structures such as lysosomes. The present review focuses on the specific functions of lysosomal cysteine proteases and the potential effects of modulators of cysteine protease activity.
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Cite this article as:
Buhling Frank, Groneberg David and Welte Tobias, Proteases and Their Role in Chronic Inflammatory Lung Diseases, Current Drug Targets 2006; 7 (6) . https://dx.doi.org/10.2174/138945006777435362
DOI https://dx.doi.org/10.2174/138945006777435362 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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