Does Human Alpha-Synuclein Behave Like Prions?

Author(s): Yasir H. Siddique*

Journal Name: CNS & Neurological Disorders - Drug Targets
Formerly Current Drug Targets - CNS & Neurological Disorders

Volume 20 , Issue 6 , 2021


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Abstract:

Alpha-synuclein (α-synuclein) is a protein that is abundantly found in the brain and in a lesser amount in the heart and muscles. The exact role of α-synucleinis is not known, but it is considered to control the movement of synaptic vesicles. Its overexpression in the neurons leads to the formation of Lewy bodies that damage the dopaminergic neurons in the subtantianigra of the midbrain and leads to the progression of Parkinson’s Disease (PD). There are evidences showing that aggregates of α-synuclein behave like prions. The present review is an attempt to put forth the nature of α-synuclein as prions.

Keywords: α-synuclein, Parkinson's disease, prions, human, Lewy bodies, synaptic vesicles.

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Article Details

VOLUME: 20
ISSUE: 6
Year: 2021
Published on: 20 April, 2021
Page: [480 - 486]
Pages: 7
DOI: 10.2174/1871527320666210420140123
Price: $65

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