Background: Curcumin demonstrated many pharmacological effects including antioxidants, anti-inflammation, eliminating free
radicals, anti-tumor, lipid regulation, and anti-coagulation.
Objective: This study aimed to assess and compare curcumin and nano-curcumin effects on lipid profile, oxidative stress, and inflammatory
factors related to patients ‘heart.
Method: This randomized, double-blind, placebo-controlled clinical trial was conducted on 90 patients undergoing coronary elective
angioplasty which were randomly divided into 3 groups. The doses administered for 8 weeks were a 500 mg capsule of curcumin daily for
the first group and an 80 mg capsule of nano-curcumin for the second group. However, the placebo group received capsules like curcumin.
Lipid profile, oxidative stress factors, and inflammatory markers were measured at the baseline and end of the experiment.
Results: Statistically significant changes were observed in the total cholesterol (TC), triacylglycerol (TG) and low-density lipoprotein
cholesterol (LDL-C) in the intervention groups to the control group (p<0.05). Curcumin and nano-curcumin supplementation also improved
significant changes in plasma levels of total antioxidant capacity (TAC), malondialdehyde (MDA), Superoxide dismutase (SOD),
glutathione peroxidase (GSH-Px), high-sensitivity C-reactive protein (hs-CRP), Interleukin 1 beta (IL-1β) and tumor necrosis factor-alpha
(TNF-α) in comparison to the placebo (p<0.05). Furthermore, the nano-curcumin group compared to the curcumin group demonstrated
significant changes (p<0.05) in TC, TG, SOD, MDA and TNF-α levels.
Conclusion: The effects of curcumin on nano formula may be better for cardiac patients due to its high bioavailability.