Oncolytic Coxsackievirus and the Mechanisms of its Effects on Cancer: A Narrative Review

Author(s): Ali Ahmadi, Hadi E.G. Ghaleh*, Ruhollah Dorostkar, Mahdieh Farzanehpour, Masoumeh Bolandian

Journal Name: Current Cancer Therapy Reviews

Volume 17 , Issue 3 , 2021

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Graphical Abstract:


Cancer is a genetic disease triggered by gene mutations, which control cell growth and their functionality inherited from previous generations. The targeted therapy of some tumors was not especially successful. A host of new techniques can be used to treat aptamer-mediated targeting, cancer immunotherapy, cancer stem cell (CSC) therapy, cell-penetrating peptides (CPPs), hormone therapy, intracellular cancer cell targeting, nanoparticles, and viral therapy. These include chemical-analog conjugation, gene delivery, ligand-receptor-based targeting, prodrug therapies, and triggered release strategies. Virotherapy is a biotechnological technique for turning viruses into therapeutic agents by the reprogramming of viruses to cure diseases. In several tumors, including melanoma, multiple myeloma, bladder cancer, and breast cancer, the oncolytic capacity of oncolytic Coxsackievirus has been studied. The present study aims to assess oncolytic Coxsackievirus and its mechanisms of effect on cancer cells.

Keywords: Cancer, viral therapy, targeted therapy, oncolytic viruses, coxsackievirus, viral vectors.

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Article Details

Year: 2021
Published on: 28 December, 2020
Page: [173 - 178]
Pages: 6
DOI: 10.2174/1573394716999201228215537
Price: $65

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PDF: 257