Background: LncRNA is a kind of non-coding RNA and its research is more popular in recent years, which has
more than 200 nucleotides. It plays a significant part in a variety of biological functions, including chromosome
modification, genome modification, transcriptional activation, transcriptional interference, and other processes. FTX, at the
center of the X chromosome inactivation, it was showed that lncRNA FTX regulates cancer cells’ development, migration
and invasion in many studies.
Methods: Relevant literatures were collected through PubMed system search and summarized.
Results: LncRNA FTX abnormally increased in tumor cells, such as liver cancer, stomach cancer, leukemia, renal cell
carcinoma, colorectal cancer, glioma, osteosarcoma, etc. However, the expression level decreased in temporal lobe epilepsy,
liver cirrhosis, heart failure, etc.
Conclusion: FTX may be an important regulatory factor and a potential therapeutic target in cancers.