The Role of STAT3 Signaling in Different Types of Cancers: A Comprehensive Review

Author(s): Kaviarasan Lakshmanan, Gowramma Byran*, Sravanthi Bandlamudi, Praveen Thaggikuppe Krishnamurthy

Journal Name: Current Enzyme Inhibition

Volume 16 , Issue 3 , 2020

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Abstract:

Signal transducer and activator of transcription (STAT3) is an important transcription factor capable of mediating or even driving cancer progression through hyperactivation or gain-offunction mutations. It plays a key role in regulating host immune and inflammatory responses and in the pathogenesis of many cancers. However, compelling evidence suggests that STAT3 is constitutively activated in many cancers and plays a vital role in tumor growth and metastasis. Hyperactive STAT3 is also implicated in various hematopoietic and solid malignancies, such as chronic and acute myeloid leukemia, melanoma or prostate cancer. The classical understanding of STAT functions is linked to their phosphorylated parallel dimer conformation, in which they induce gene transcription. In this review, we discuss the functions and the roles of STAT3 signal in various types of cancers.

Keywords: Cancer, gene transcription, hyperactivation, phosphorylation, solid tumor, STAT3.

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Article Details

VOLUME: 16
ISSUE: 3
Year: 2020
Page: [189 - 198]
Pages: 10
DOI: 10.2174/1573408016999200708160300
Price: $95

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