Title:Interleukin 1-beta is Linked to Chronic Low-Grade Inflammation and Cardiovascular Risk Factors in Overweight Adolescents
VOLUME: 20 ISSUE: 6
Author(s):Gisele A. Amaral, Josilene D. Alves, Adenilda C. Honorio-França, Danny L. Fagundes, Gabriel Gomes Araujo, Nubia S. Lobato, Victor V. Lima and Fernanda R. Giachini*
Affiliation:Institute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garcas, MT, Institute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garcas, MT, Institute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garcas, MT, Institute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garcas, MT, Institute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garcas, MT, Department of Biological Sciences, Division of Cardiovascular Physiology, Federal University of Goias, Jatai, Institute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garcas, MT, Institute of Biological and Health Sciences, Federal University of Mato Grosso, Barra do Garcas, MT
Keywords:Childhood, obesity, cytokine, inflammation, dyslipidemia, interleukins.
Abstract:
Aim: We hypothesized that IL-1β concentrations are augmented in overweight adolescents,
who do not display metabolic syndrome. Additionally, we aimed to correlate the IL-1β concentrations
with several established risk factors for CVD.
Methods: Overweight or control subjects, aging from 14-18 years, were classified according to their
adjusted body mass index and evaluated for biochemical and anthropometric parameters. The proinflammatory
cytokine IL-1β was assessed in the serum.
Results: Increased body fat percentage, waist circumference, triglycerides, total cholesterol, Very
Low-Density Lipoprotein (VLDL) cholesterol, Low-Density Lipoprotein (LDL) cholesterol, Castelli I
index, IL-1β, and IL-8 levels, were observed in overweight adolescents. No differences were observed
in systolic blood pressure, diastolic blood pressure, glucose or High-Density Lipoprotein (HDL) cholesterol.
Positive correlations between IL-1β with anthropometric and or biochemical parameters were
found.
Conclusion: In conclusion, increased IL-1β levels correlate to dyslipidemic factors and may further
support low-grade inflammation. IL-1β may further predict the early onset of cardiovascular disease in
this population, taking into consideration its important regulatory role.