Chemically Nano-Engineered Theranostics for Phytoconstituents as Healthcare Application

Author(s): Sadaf Jamal Gilani, Sarwar Beg, Chandra Kala, Mohammed Shivli Nomani, Debarshi Kar Mahapatra, Syed Sarim Imam, Mohamad Taleuzzaman*

Journal Name: Current Biochemical Engineering

Volume 6 , Issue 1 , 2020

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Graphical Abstract:


Background: Nanomedicines are capable of disease diagnosis, drug delivery, and in monitoring the therapeutic result to provide appropriate tasks towards research goals. The best therapeutic pattern can be achieved by developing a theranostic nanomedicine, which is an emerging field. It has the advantage of loading phytoconstituents as drugs and is useful for both imaging and therapeutic function.

Methods: Nowadays, the design of a novel drug delivery system of the herbal constituent is usually done through the nanotechnology approach. This technique increases the biological activity and counters the puzzles associated with plant medicines. Traditional medicine integration with nanocarriers as an NDDS is very essential in the management of chronic diseases such as hypertension, diabetes, and cancer.

Results: The nanotechnology combination with plant science is a green revolution with a practical approach for decreasing the therapeutic side effects. The object of the study is to review herbal nanomedicine with an enhanced therapeutic profile and less toxicity.

Conclusion: The development of herbal theranostic nanoformulation is very useful for the treatment of different diseases.

Keywords: Nanomedicine, phytoconstituents, NDDSs, bioavailability, theranostics, healthcare application.

A.T. Sharma, S.S. Mitkare, and R.S. Moon, "Multicomponent herbal therapy: A review", Int. J. Pharm. Sci. Rev. Res., vol. 6, pp. 185-187, 2011.
B. Patwardhan, A.D. Vaidya, and M. Chorghade, "Ayurveda and natural products drug discovery", Curr. Sci., vol. 86, pp. 789-799, 2004.
S. Bisht, G. Feldmann, S. Soni, R. Ravi, C. Karikar, A. Maitra, and A. Maitra, "Polymeric nanoparticle-encapsulated curcumin (“nanocurcumin”): A novel strategy for human cancer therapy", J. Nanobiotechnology, vol. 5, p. 3, 2007.
[] [PMID: 17439648]
L. Zheng, and J.F. Song, "Curcumin multi-wall carbon nanotubes modified glassy carbon electrode and its electrocatalytic activity towards oxidation of hydrazine", Sens. Actuators B Chem., vol. 135, pp. 650-655, 2009.
D. Yadav, S. Suri, A.A. Choudhary, M. Sikender, and N.M. Hemant, "Beg Novel approach: Herbal remedies and natural products in pharmaceutical science as nano drug delivery systems", Int. J. Pharm. Tech., vol. 3, no. 30, pp. 92-116, 2011.
S.H. Ansari, F. Islam, and M. Sameem, "Influence of nanotechnology on herbal drugs: A Review", J. Adv. Pharm. Technol. Res., vol. 3, no. 3, pp. 142-146, 2012.
[] [PMID: 23057000]
J.C. Pickup, Z.L. Zhi, F. Khan, T. Saxl, and D.J.S. Birch, "Nanomedicine and its potential in diabetes research and practice", Diabetes Metab. Res. Rev., vol. 24, no. 8, pp. 604-610, 2008.
[] [PMID: 18802934]
M.S. Harsoliya, V.M. Patel, and M. Modasiya, "Recent advances & applications of nanotechnology in diabetes", Int. J. Pharm. Biol. Arch., vol. 3, pp. 255-261, 2012.
W. Stober, A. Fink, and E. Bohn, "Controlled growth of monodisperse silica spheres in the micron size range", J. Colloid Interface Sci., vol. 26, pp. 62-69, 1968.
B. Chertok, M.J. Webber, M.D. Succi, and R. Langer, "Drug delivery interfaces in the 21st century: from science fiction ideas to viable technologies", Mol. Pharm., vol. 10, no. 10, pp. 3531-3543, 2013.
[] [PMID: 23915375]
K.M. Bratlie, R.L. York, M.A. Invernale, R. Langer, and D.G. Anderson, "Materials for diabetes therapeutics", Adv. Healthc. Mater., vol. 1, no. 3, pp. 267-284, 2012.
[] [PMID: 23184741]
J.V. Veetil, S. Jin, and K. Ye, "Fluorescence lifetime imaging microscopy of intracellular glucose dynamics", J. Diabetes Sci. Technol., vol. 6, no. 6, pp. 1276-1285, 2012.
[] [PMID: 23294772]
C. Shan, H. Yang, D. Han, Q. Zhang, A. Ivaska, and L. Niu, "Graphene/AuNPs/chitosan nanocomposites film for glucose biosensing", Biosens. Bioelectron., vol. 25, no. 5, pp. 1070-1074, 2010.
[] [PMID: 19883999]
K. Besteman, J.O. Lee, F.G.M. Wiertz, H.A. Heering, and C. Dekker, "Enzyme-coated carbon nanotubes as single-molecule biosensors", Nano Lett., vol. 3, pp. 727-730, 2003.
Q. Wu, L. Wang, H. Yu, J. Wang, and Z. Chen, "Organization of glucose-responsive systems and their properties", Chem. Rev., vol. 111, no. 12, pp. 7855-7875, 2011.
[] [PMID: 21902252]
H.Y. Hung, K. Qian, S.L. Morris-Natschke, C.S. Hsu, and K.H. Lee, "Recent discovery of plant-derived anti-diabetic natural products", Nat. Prod. Rep., vol. 29, no. 5, pp. 580-606, 2012.
[] [PMID: 22491825]
L.A. Torre, F. Bray, R.L. Siegel, J. Ferlay, J. Lortet-Tieulent, and A. Jemal, "Global cancer statistics, 2012", CA Cancer J. Clin., vol. 65, no. 2, pp. 87-108, 2015.
[] [PMID: 25651787]
D. Alberti, N. Protti, A. Toppino, A. Deagostino, S. Lanzardo, S. Bortolussi, S. Altieri, C. Voena, R. Chiarle, S. Geninatti Crich, and S. Aime, "A theranostic approach based on the use of a dual boron/Gd agent to improve the efficacy of Boron Neutron Capture Therapy in the lung cancer treatment", Nanomedicine (Lond.), vol. 11, no. 3, pp. 741-750, 2015.
[] [PMID: 25596074]
Z. Ge, and S. Liu, "Functional block copolymer assemblies responsive to tumor and intracellular microenvironments for site-specific drug delivery and enhanced imaging performance", Chem. Soc. Rev., vol. 42, no. 17, pp. 7289-7325, 2013.
[] [PMID: 23549663]
S. Gelperina, K. Kisich, M.D. Iseman, and L. Heifets, "The potential advantages of nanoparticle drug delivery systems in chemotherapy of tuberculosis", Am. J. Respir. Crit. Care Med., vol. 172, no. 12, pp. 1487-1490, 2005.
[] [PMID: 16151040]
R. Pérez-Tomás, "Multidrug resistance: retrospect and prospects in anti-cancer drug treatment", Curr. Med. Chem., vol. 13, no. 16, pp. 1859-1876, 2006.
[] [PMID: 16842198]
S.M. Janib, A.S. Moses, and J.A. MacKay, "Imaging and drug delivery using theranostic nanoparticles", Adv. Drug Deliv. Rev., vol. 62, no. 11, pp. 1052-1063, 2010.
[] [PMID: 20709124]
K.C. Nicolaou, Z. Yang, J.J. Liu, H. Ueno, P.G. Nantermet, R.K. Guy, C.F. Claiborne, J. Renaud, E.A. Couladouros, and K. Paulvannan, "Total synthesis of taxol", Nature, vol. 367, no. 6464, pp. 630-634, 1994.
[] [PMID: 7906395]
S.M.K. Rates, "Plants as source of drugs", Toxicon, vol. 39, no. 5, pp. 603-613, 2001.
[] [PMID: 11072038]
S. Donnellan, V. Stone, H. Johnston, M. Giardiello, A. Owen, S. Rennard, G. Aljayyoussi, B. Swift, L. Tran, C. Watkins, and K. Stevenso, "Intracellular delivery of nano-formulated antituberculosis drugs enhances bactericidal activity", J. Interdiscip. Nanomed., vol. 2, no. 3, pp. 146-157, 2017.
S. Donnellan, L. Tran, H. Johnston, J. McLuckie, K. Stevenson, and V. Stone, "A rapid screening assay for identifying mycobacteria targeted nanoparticle antibiotics", Nanotoxicology, vol. 10, no. 6, pp. 761-769, 2016.
[] [PMID: 26618564]
O. Bondarenko, A. Ivask, A. Käkinen, and A. Kahru, "Sub-toxic effects of CuO nanoparticles on bacteria: kinetics, role of Cu ions and possible mechanisms of action", Environ. Pollut., vol. 169, pp. 81-89, 2012.
[] [PMID: 22694973]
S. Mohanty, P. Jena, R. Mehta, R. Pati, B. Banerjee, S. Patil, and A. Sonawane, "Cationic antimicrobial peptides and biogenic silver nanoparticles kill mycobacteria without eliciting DNA damage and cytotoxicity in mouse macrophages", Antimicrob. Agents Chemother., vol. 57, no. 8, pp. 3688-3698, 2013.
[] [PMID: 23689720]
R. Pandey, and G.K. Khuller, "Solid lipid particle-based inhalable sustained drug delivery system against experimental tuberculosis", Tuberculosis (Edinb.), vol. 85, no. 4, pp. 227-234, 2005.
[] [PMID: 15922668]
T.O. McDonald, M. Giardiello, P. Martin, M. Siccardi, N.J. Liptrott, D. Smith, P. Roberts, P. Curley, A. Schipani, S.H. Khoo, J. Long, A.J. Foster, S.P. Rannard, and A. Owen, "Antiretroviral solid drug nanoparticles with enhanced oral bioavailability: production, characterization, and in vitro-in vivo correlation", Adv. Healthc. Mater., vol. 3, no. 3, pp. 400-411, 2014.
[] [PMID: 23997027]
B. Wang, "Targeted drug delivery to intestinal macrophages by bioactive nanovesicles released from grapefruit", Molecular therapy: the journal of the American Society of Gene Therapy. vol. 22, pp. 522-534, March 2014
P.E. Williams, H.M. Crauwels, and E.D. Basstanie, "Formulation and pharmacology of long-acting rilpivirine", Curr. Opin. HIV AIDS, vol. 10, no. 4, pp. 233-238, 2015.
[] [PMID: 26049947]
Zulueta. A, "Caretti, P. Signorelli, and R. Ghidoni, “Resveratrol: A potential challenger against gastric cancer", World J. Gastroenterol., vol. 21, no. 37, pp. 10636-10643, 2015.
[] [PMID: 26457023]
E.C. Filippi-Chiela, M.P. Thomé, M.M. Bueno e Silva, A.L. Pelegrini, P.F. Ledur, B. Garicochea, L.L. Zamin, and G. Lenz, "Resveratrol abrogates the temozolomide-induced G2 arrest leading to mitotic catastrophe and reinforces the temozolomide-induced senescence in glioma cells", BMC Cancer, vol. 13, pp. 147-160, 2013.
[] [PMID: 23522185]
M. Taleuzzaman, and V. Kumar, "Recent complications and issues in tuberculosis treatment", Recent Pat Antiinfect Drug Discov, vol. 12, no. 2, pp. 138-146, 2017.
[] [PMID: 28990538]
H. Huang, H. Lin, X. Zhang, and J. Li, "Resveratrol reverses temozolomide resistance by downregulation of MGMT in T98G glioblastoma cells by the NF-κB-dependent pathway", Oncol. Rep., vol. 27, no. 6, pp. 2050-2056, 2012.
[PMID: 22426504]
X. Li, R. Li, X. Qian, Y. Ding, Y. Tu, R. Guo, Y. Hu, X. Jiang, W. Guo, and B. Liu, "Superior antitumor efficiency of cisplatin-loaded nanoparticles by intratumoral delivery with decreased tumor metabolism rate", Eur. J. Pharm. Biopharm., vol. 70, no. 3, pp. 726-734, 2008.
[] [PMID: 18634874]
H. Zhang, X. Li, J. Ding, H. Xu, X. Dai, Z. Hou, K. Zhang, K. Sun, and W. Sun, "Delivery of ursolic acid (UA) in polymeric nanoparticles effectively promotes the apoptosis of gastric cancer cells through enhanced inhibition of cyclooxygenase 2 (COX-2)", Int. J. Pharm., vol. 441, no. 1-2, pp. 261-268, 2013.
[] [PMID: 23194884]
A. Teichmann, S. Heuschkel, U. Jacobi, G. Presse, R.H. Neubert, W. Sterry, and J. Lademann, "Comparison of stratum corneum penetration and localization of a lipophilic model drug applied in an o/w microemulsion and an amphiphilic cream", Eur. J. Pharm. Biopharm., vol. 67, no. 3, pp. 699-706, 2007.
[] [PMID: 17537622]
M.H. Schmid, and H.C. Korting, "Therapeutic progress with topical liposome drugs for skin disease", Adv. Drug Deliv. Rev., vol. 18, pp. 479-489 October, 1996.
M. Foldvari, A. Gesztes, and M. Mezei, "Dermal drug delivery by liposome encapsulation: clinical and electron microscopic studies", J. Microencapsul., vol. 7, no. 4, pp. 479-489, 1990.
[] [PMID: 2266473]
H.C. Korting, H. Zienicke, M. Schäfer-Korting, and O. Braun-Falco, "Liposome encapsulation improves efficacy of betamethasone dipropionate in atopic eczema but not in psoriasis vulgaris", Eur. J. Clin. Pharmacol., vol. 39, no. 4, pp. 349-351, 1990.
[] [PMID: 2076716]
M.M. Elsayed, O.Y. Abdallah, V.F. Naggar, and N.M. Khalafallah, "Deformable liposomes and ethosomes as carriers for skin delivery of ketotifen", Pharmazie, vol. 62, no. 2, pp. 133-137, 2007.
[PMID: 17341034]
C. Valenta, and M. Janisch, "Permeation of cyproterone acetate through pig skin from different vehicles with phospholipids", Int. J. Pharm., vol. 258, no. 1-2, pp. 133-139, 2003.
[] [PMID: 12753760]
B. Pang, L.H. Zhao, Q. Zhou, T.Y. Zhao, H. Wang, C.J. Gu, and X.L. Tong, "Application of berberine on treating type 2 diabetes mellitus", Int. J. Endocrinol.vol. 2015, no. February, 2015.905749,
[] [PMID: 25861268]
B.G. Switi, G.K. Mohan, and M.S. Rani, "Phytochemicals for diabetes management", Pharmaceutical Crops., vol. 5, pp. 11-28, 2013.
M. Leena, "Catharanthusroseus leavesasan anti-diabetic hypolipidemic agents alloxan-induced diabetic rats", American J. of Phytomedicine and Clin. Therapeu., vol. 2, no. 12, pp. 1393-1396, 2014.
M. Ayyanar, and P. Subash-Babu, "Syzygium cumini (L.) Skeels: a review of its phytochemical constituents and traditional uses", Asian Pac. J. Trop. Biomed., vol. 2, no. 3, pp. 240-246, 2012.
[] [PMID: 23569906]
B. Switi, G. Gaikwad, M. Krishna, and M.S. Rani, "Phytochem. for Diabet", Manag. Pharma. Crops, vol. 5, no. 1, pp. 11-28, 2014.
L. Nahar, R. Zahan, and A. Mosaddik, "Antioxidant and antitumor activity of chloroform extract of Alangium salvifolium flowers", Phytopharmacology., vol. 2, no. 1, pp. 123-134, 2012.
T. Pecere, M.V. Gazzola, C. Mucignat, C. Parolin, F.D. Vecchia, A. Cavaggioni, G. Basso, A. Diaspro, B. Salvato, M. Carli, and G. Palù, "Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors", Cancer Res., vol. 60, no. 11, pp. 2800-2804, 2000.
[PMID: 10850417]
T. Kikuchi, K. Ishii, T. Noto, A. Takahashi, K. Tabata, T. Suzuki, and T. Akihisa, "Cytotoxic and apoptosis-inducing activities of limonoids from the seeds of Azadirachta indica (neem)", J. Nat. Prod., vol. 74, no. 4, pp. 866-870, 2011.
[] [PMID: 21381696]
D. Sajuthi, "Extraction, fractionation, and in vitro biological tested on Gynura pseudochina (Linn.) DC.) as the anticancer, second phase", Buletin Kimia. vol. 1, no. 2, 2001
L. Prasad, T.H. Khan, T. Jahangir, and S. Sultana, "Acorus calamus extracts and nickel chloride: prevention of oxidative damage and hyperproliferation response in rat kidney", Biol. Trace Elem. Res., vol. 113, no. 1, pp. 77-92, 2006.
[] [PMID: 17114817]
D. Lakshmanan, J. Werngren, L. Jose, K.P. Suja, M.S. Nair, R.L. Varma, S. Mundayoor, S. Hoffner, and R.A. Kumar, "Ethyl p-methoxycinnamate isolated from a traditional anti-tuberculosis medicinal herb inhibits drug resistant strains of Mycobacterium tuberculosis in vitro", Fitoterapia, vol. 82, no. 5, pp. 757-761, 2011.
[] [PMID: 21459133]
S. Sureram, S.P. Senadeera, P. Hongmanee, C. Mahidol, S. Ruchirawat, and P. Kittakoop, "Antimycobacterial activity of bisbenzylisoquinoline alkaloids from Tiliacora triandra against multidrug-resistant isolates of Mycobacterium tuberculosis", Bioorg. Med. Chem. Lett., vol. 22, no. 8, pp. 2902-2905, 2012.
[] [PMID: 22418278]
T.L. Mader, and M.C. Brumm, "Effect of feeding Sarsaponin in cattle and swine diets", J. Anim. Sci., vol. 65, no. 1, pp. 9-15, 1987.
[] [PMID: 3610886]
J.D.N. Guessan, A.P. Bidié, B.N. Lenta, B. Weniger, P. André, and F. Guédé-Guina, "In vitro assays for bioactivity-guided isolation of anti-salmonella and antioxidant compounds in Thonningia sanguine flowers", Afr. J. Biotechnol., vol. 6, no. 14, pp. 1685-1689, 2007.
N. Sultana, and N.H. Lee, "Antielastase and free radical scavenging activities of compounds from the stems of Cornus kousa", Phytother. Res., vol. 21, no. 12, pp. 1171-1176, 2007.
[] [PMID: 17661332]
S. Pahadiya, and J. Sharma, "Alteration of lethal effects of gamma rays in Swiss albino mice by Tinospora cordifolia", Phytother. Res., vol. 17, no. 5, pp. 552-554, 2003.
[] [PMID: 12748997]
C. Gauthier, J. Legault, M. Lebrun, P. Dufour, and A. Pichette, "Glycosidation of lupane-type triterpenoids as potent in vitro cytotoxic agents", Bioorg. Med. Chem., vol. 14, no. 19, pp. 6713-6725, 2006.
[] [PMID: 16787747]
P.K. Visen, B. Shukla, G.K. Patnaik, and B.N. Dhawan, "Andrographolide protects rat hepatocytes against paracetamol-induced damage", J. Ethnopharmacol., vol. 40, no. 2, pp. 131-136, 1993.
[] [PMID: 8133653]
R. Sharma, and J. Sharma, "Modification of gamma ray induced changes in the mouse hepatocytes by Centella asiatica extract: in vivo studies", Phytother. Res., vol. 19, no. 7, pp. 605-611, 2005.
[] [PMID: 16161023]
B.B. Aggarwal, A. Kumar, and A.C. Bharti, "Anticancer potential of curcumin: preclinical and clinical studies", Anticancer Res., vol. 23, no. 1A, pp. 363-398, 2003.
[PMID: 12680238]
M. Rahman, S. Beg, A. Verma, I. Kazmi, D.K. Patel, F. Anwar, F.A. Al Abbasi, and V. Kumar, "Therapeutic applications of liposomal-based drug delivery and drug targeting for immune linked inflammatory maladies: A contemporary viewpoint", Curr. Drug Targets, vol. 18, no. 13, pp. 1558-1571, 2017.
[] [PMID: 28413980]
S. Beg, M. Rahman, A. Jain, S. Saini, P. Midoux, C. Pichon, F.J. Ahmad, and S. Akhter, "Nanoporous metal organic frameworks as hybrid polymer-metal composites for drug delivery and biomedical applications", Drug Discov. Today, vol. 22, no. 4, pp. 625-637, 2017.
[] [PMID: 27742533]
M. Rahman, V. Kumar, S. Beg, G. Sharma, O.P. Katare, and F. Anwar, "Emergence of liposome as targeted magic bullet for inflammatory disorders: current state of the art", Artif. Cells Nanomed. Biotechnol., vol. 44, no. 7, pp. 1597-1608, 2016.
[] [PMID: 26758815]
J. Ahmad, S. Akhter, M. Rizwanullah, S. Amin, M. Rahman, M.Z. Ahmad, M.A. Rizvi, M.A. Kamal, and F.J. Ahmad, "Nanotechnology-based inhalation treatments for lung cancer: state of the art", Nanotechnol. Sci. Appl., vol. 8, no. 8, pp. 55-66, 2015.
[PMID: 26640374]
J. Ahmad, S. Amin, M. Rahman, R.A. Rub, M. Singhal, M.Z. Ahmad, Z. Rahman, R.T. Addo, F.J. Ahmad, G. Mushtaq, M.A. Kamal, and S. Akhter, "Solid matrix based lipidic nanoparticles in oral cancer chemotherapy: Applications and pharmacokinetics", Curr. Drug Metab., vol. 16, no. 8, pp. 633-644, 2015.
[] [PMID: 26264206]
M. Rahman, S. Akhter, M.Z. Ahmad, J. Ahmad, R.T. Addo, F.J. Ahmad, and C. Pichon, "Emerging advances in cancer nanotheranostics with graphene nanocomposites: opportunities and challenges", Nanomedicine (Lond.), vol. 10, no. 15, pp. 2405-2422, 2015.
[] [PMID: 26252175]
P. Aneja, M. Rahman, S. Beg, S. Aneja, V. Dhingra, and R. Chugh, "Cancer targeted magic bullets for the effective treatment of cancer", Recent Pat. Antiinfect Drug Discov., vol. 2, pp. 121-135, 2014.
M.Z. Ahmad, S. Akhter, M. Anwar, A. Kumar, M. Rahman, A.H. Talasaz, and F.J. Ahmad, "Colorectal cancer targeted Irinotecan-Assam Bora rice starch based microspheres: a mechanistic, pharmacokinetic and biochemical investigation", Drug Dev. Ind. Pharm., vol. 39, no. 12, pp. 1936-1943, 2013.
[] [PMID: 23013140]
M. Rahman, M.Z. Ahmad, I. Kazmi, S. Akhter, M. Afzal, G. Gupta, F. Jalees Ahmed, and F. Anwar, "Advancement in multifunctional nanoparticles for the effective treatment of cancer", Expert Opin. Drug Deliv., vol. 9, no. 4, pp. 367-381, 2012.
[] [PMID: 22400808]
M. Taleuzzaman, S.S. Imam, and S.J. Gilani, "Quantitative Determination of thymoquinone in Nigella Sativa and its nano formulation using validated stability indicating HPTLC densiometric method", Int. Curr. Pharm. J., vol. 6, no. 10, pp. 53-60, 2017.
M. Rahman, M.Z. Ahmad, I. Kazmi, S. Akhter, M. Afzal, G. Gupta, and V.R. Sinha, "Emergence of nanomedicine as cancer targeted magic bullets: recent development and need to address the toxicity apprehension", Curr. Drug Discov. Technol., vol. 9, no. 4, pp. 319-329, 2012.
[] [PMID: 22725687]
V. Kumar, P.C. Bhatt, M. Rahman, G. Kaithwas, H. Choudhry, F.A. Al-Abbasi, F. Anwar, and A. Verma, "Fabrication, optimization, and characterization of umbelliferone β-D-galactopyranoside-loaded PLGA nanoparticles in treatment of hepatocellular carcinoma: in vitro and in vivo studies", Int. J. Nanomedicine, vol. 12, pp. 6747-6758, 2017.
[] [PMID: 28932118]
M. Jamal, S.S. Imam, M. Aqil, M. Amir, S.R. Mir, and M. Mujeeb, "Transdermal potential and anti-arthritic efficacy of ursolic acid from niosomal gel systems", Int. Immunopharmacol., vol. 29, no. 2, pp. 361-369 December, 2015.
M. Akhtar, S.S. Imam, M.A. Ahmad, A.K. Najmi, M. Mujeeb, and M. Aqil, "Neuroprotective study of Nigella sativa-loaded oral provesicular lipid formulation: in vitro and ex vivo study", Drug Deliv., vol. 21, no. 6, pp. 487-494 September, 2014.
L. Abidin, M. Mujeeb, S.S. Imam, M. Aqil, and D. Khurana, "Enhanced transdermal delivery of luteolin via non-ionic surfactant-based vesicle: quality evaluation and anti-arthritic assessment", Drug Deliv., vol. 23, no. 3, pp. 1079-1084, 2016.
[] [PMID: 25116512]
S. Sayeed, S.S. Imam, A.K. Najmi, M. Aqil, and M. Akhtar, "Nonionic surfactant based thymoquinone loaded nanoproniosomal formulation: in vitro physicochemical evaluation and in vivo hepatoprotective efficacy", Drug Dev. Ind. Pharm., vol. 43, no. 9, pp. 1413-1420, 2017.
[] [PMID: 28402205]
K. Shakeel, S. Raisuddin, S. Ali, S.S. Imam, M.A. Rahman, G.K. Jain, and F.J. Ahmad, "Development and in vitro/in vivo evaluation of artemether and lumefantrine co-loaded nanoliposomes for parenteral delivery", J. Liposome Res., vol. 29, no. 1, pp. 35-43, 2019.
[] [PMID: 29179636]
M. Alam, A.K. Najmi, I. Ahmad, F.J. Ahmad, M.J. Akhtar, S.S. Imam, and M. Akhtar, "Formulation and evaluation of nano lipid formulation containing CNS acting drug: molecular docking, invitro assessment and bioactivity detail in rats", Artif. Cells Nanomed. Biotechnol. vol. 46, no. sup2, pp. 46-57, 2018
[] [PMID: 29560744]
K. Khan, M. Aqil, S.S. Imam, A. Ahad, T. Moolakkadath, Y. Sultana, and M. Mujeeb, "Ursolic acid loaded intra nasal nano lipid vesicles for brain tumour: Formulation, optimization, in-vivo brain/plasma distribution study and histopathological assessment", Biomed. Pharmacother., vol. 106, pp. 1578-1585, 2018.
[] [PMID: 30119233]
T. Moolakkadath, M. Aqil, A. Ahad, S.S. Imam, A. Praveen, Y. Sultana, M. Mujeeb, and Z. Iqbal, "Fisetin loaded binary ethosomes for management of skin cancer by dermal application on UV exposed mice", Int. J. Pharm., vol. 560, pp. 78-91, 2019.
[] [PMID: 30742987]

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Article Details

Year: 2020
Published on: 23 July, 2019
Page: [53 - 61]
Pages: 9
DOI: 10.2174/2212711906666190723144111

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