Impact of Curcumin on Traumatic Brain Injury and Involved Molecular Signaling Pathways

Author(s): Tahereh Farkhondeh, Saeed Samarghandian*, Babak Roshanravan, Leila Peivasteh-roudsari

Journal Name: Recent Patents on Food, Nutrition & Agriculture

Volume 11 , Issue 2 , 2020


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Graphical Abstract:


Abstract:

Traumatic Brain Injury (TBI) is one of the main causes of mortality and morbidity worldwide with no suitable treatment. The present study was designed to review the present literature about the protective effects of curcumin and the underlying mechanism against TBI. All published English language papers from beginning to 2019 were selected in this study. The findings indicate that curcumin may be effective against TBI outcomes by modulating the molecular signaling pathways involved in oxidative stress, inflammation, apoptosis, and autophagy. However, more experimental studies should be done to identify all mechanisms involved in the pathogenesis of TBI. Patents for Curcumin and chronic inflammation and traumatic brain injury management (WO2017097805A1 and US9101580B2) were published. In conclusion, the present study confirmed the potential therapeutic impact of curcumin for treating TBI.

Keywords: Curcumin, traumatic brain injury, inflammation, oxidative stress, apoptosis, autophagy.

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VOLUME: 11
ISSUE: 2
Year: 2020
Published on: 17 June, 2019
Page: [137 - 144]
Pages: 8
DOI: 10.2174/2212798410666190617161523

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