Introduction: Peripheral nerve lesion is a common clinical problem that may produce longterm
functional defects. Usually, crush injuries, fractures, scars, lacerations, compression, or iatrogenic
reasons are reasons for nerve injuries. Unsuccessful treatment of nerve injuries causes partial or total
loss of sense, motor, and autonomic functions. Despite widespread experimental studies that aimed
to improve nerve healing, healing results for peripheral nerve injuries are hardly reasonable. The successes
of the regenerative procedure of the nerve repair in experimental research, with topical agents,
can be assessed using different methods such as morphological, electrophysiological, biochemical and
functional evaluation. Although, most researchers confirm that despite good microsurgical repair and
topical application of these substances, complete regeneration and functional recovery of the injured
nerves are almost never achieved.
Conclusion: This study aimed to make a comparison between topical pharmacological agents at the
peripheral nerve lesion and methods used for evaluating the success of the repair process. For this
purpose, we reviewed studies conducted on some of the most commonly used pharmacological agents
as well as their properties in the repair of peripheral nerve lesions.