Title:Recent Finding in Repair of the Peripheral Nerve Lesions Using Pharmacological Agents: Common Methods for Evaluating the Repair Process
VOLUME: 18 ISSUE: 3
Author(s):Dheyauldeen Shabeeb, Masoud Najafi, Mansor Keshavarz, Ahmed Eleojo Musa, Gholamreza Hassanzadeh, Mohammed Reza Hadian and Alireza Shirazi*
Affiliation:Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran University of Medical Science, Tehran, Radiology and Nuclear Medicine Department, School of Paramedical Sciences, Kermanshah University of Medical Sciences, Kermanshah, Department of Physiology, School of Medicine, Tehran University of Medical Science, Tehran, Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran University of Medical Science, Tehran, Department of Anatomy, School of Medicine, Tehran University of Medical Science, Tehran, Brain and Spinal Injury Repair Research Center, Tehran University of Medical Science, Tehran, Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran University of Medical Science, Tehran
Keywords:Biochemical, electrophysiological, functional evaluation, histo-morphological, peripheral nerve injury, peripheral
nerve, pharmaceutical agents.
Abstract:Introduction: Peripheral nerve lesion is a common clinical problem that may produce longterm
functional defects. Usually, crush injuries, fractures, scars, lacerations, compression, or iatrogenic
reasons are reasons for nerve injuries. Unsuccessful treatment of nerve injuries causes partial or total
loss of sense, motor, and autonomic functions. Despite widespread experimental studies that aimed
to improve nerve healing, healing results for peripheral nerve injuries are hardly reasonable. The successes
of the regenerative procedure of the nerve repair in experimental research, with topical agents,
can be assessed using different methods such as morphological, electrophysiological, biochemical and
functional evaluation. Although, most researchers confirm that despite good microsurgical repair and
topical application of these substances, complete regeneration and functional recovery of the injured
nerves are almost never achieved.
Conclusion: This study aimed to make a comparison between topical pharmacological agents at the
peripheral nerve lesion and methods used for evaluating the success of the repair process. For this
purpose, we reviewed studies conducted on some of the most commonly used pharmacological agents
as well as their properties in the repair of peripheral nerve lesions.
