Ellagic Acid: A Logical Lead for Drug Development?

Author(s): Abolfazl Shakeri, Mohammad Reza Zirak, Amirhossein Sahebkar*

Journal Name: Current Pharmaceutical Design

Volume 24 , Issue 2 , 2018


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Abstract:

Background: Naturally occurring polyphenols are the subject of increasing attention due to their potent antioxidant activity and their marked effects on the prevention of various oxidative stress-associated diseases such as cancer. Ellagic acid (EA) is an herbal polyphenol that is structurally a condensed dimer of gallic acid.

Methods: This review aims to provide a comprehensive and updated overview on the biological activities of EA and potential therapeutic applications.

Results: EA is found in fruits and nuts, either in the combined form with hexahydroxydiphenic acid or in the bound form (ellagitannins). EA exhibits many biological properties such as antioxidant, anti-diabetic, anticancer and apoptosis-inducing activities. These biological and pharmacological properties are relevant to the treatment of several human diseases.

Conclusion: Owing to its multiple mechanisms of action, EA represents a potential therapeutic agent against human diseases particularly cancer.

Keywords: Polyphenol, ellagic acid, pharmacology, phytomedicine, gallic acid, antioxidant.

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Article Details

VOLUME: 24
ISSUE: 2
Year: 2018
Published on: 05 April, 2018
Page: [106 - 122]
Pages: 17
DOI: 10.2174/1381612823666171115094557
Price: $65

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