Novel Azole-Functionalited Flouroquinolone Hybrids: Design, Conventional and Microwave Irradiated Synthesis, Evaluation as Antibacterial and Antioxidant Agents

Author(s): Meltem Mentese, Neslihan Demirbas*, Arif Mermer, Serpil Demirci, Ahmet Demirbas, Faik Ahmet Ayaz

Journal Name: Letters in Drug Design & Discovery

Volume 15 , Issue 1 , 2018

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Graphical Abstract:


Background: The synthesis of new hybrid molecules consisting of several heterocyclic pharmacophores namely fluoroquinolone, 1,2,4-triazole, 1,3,4-oxadiazole and piperazine was carried out by conventional and successfully optimized microwave mediated techniques.

Methods: The structures of new compounds were confirmed using spectroscopic techniques. These compounds were screened for their antibacterial activity against E. coli, P. aeruginosa, Y. pseudotuberculosis, S. aureus, E. faecalis, B. cereus and M. smegmatis.

Results and Conclusion: Fourteen of these hybrids exhibited excellent antibacterial activities on the test microorganisms when compared with ampicillin with the mic values varying between 0.03- 0.25 µg/mL.

Keywords: Fluoroquinolone, 1, 2, 4-triazole, 1, 3, 4-oxadiazole, piperazine, antibacterial activity, antioxidant activity, microwave.

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Article Details

Year: 2018
Page: [46 - 64]
Pages: 19
DOI: 10.2174/1570180814666170823163540
Price: $65

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PDF: 28
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