MicroRNAs are small non-coding RNAs with regulatory biological activity, by modulating target
genes on epigenetic, transcriptional, post-transciptional and translational levels. Hundreds of reports indicated
that miRNAs play important roles in non-small cell lung cancer (NSCLC). Actually, microRNAs are both regulation
targets and regulators targeting effector genes. This article reviewed multifaceted role of microRNAs associated
to NSCLC, not only targeting to but also targeted by tumor related genes, to help us understand microRNAs
related complex regulation networks. Aberrant expressed micoRNAs and their targets were summarized; the
statistical results showed that several microRNAs may play key roles by targeting multiple tumor associated
targets. On the other hand, Oncogenes and tumor repressors represented by PTEN were also shown to be the most
popular targets of microRNAs. Additionally, ZEB1/2 may be a featured pathway in NSCLC, with significant
frequency modulated by microRNAs.
Keywords: Regulation mechanism, MicroRNAs, non-coding RNAs, non-small cell lung cancer (NSCLC), tumor, oncogenes.
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