Abstract
Background: Currently, existing regimens of genotoxic drugs have been suggested to be complemented with molecular inhibitors as combinatorial and cocktail approaches in malignancy.
Methods: In the last decade, attempts have been reported to test several new class of anticancer drug such as miRNA mimetics, RNA enzymes, small molecular inhibitors, DNA repair protein inhibitors and peptide mimetics.
Results: With the advent of rapidly growing genomic, epigenomic and proteomic data, design and application of peptide mimetics appear to thrive and sustain for an impactful cancer therapy. However, certain bottlenecks are envitable such as delivery of peptide mimetics drug in clinical settings, reducing the side effects, immune responses and pharmacokinetic properties.
Conclusion: This review discusses emerging issues and potential avenues related to the scope and limitations of peptide mimetics in cancer treatment.
Keywords: Cellular growth, cancer, proteomics, protein, regulation, signaling pathway, targeted therapy.
Current Cancer Therapy Reviews
Title:Therapeutic Peptide Mimetics Looking for a Turn to Block Aberrant Players of Malignancy
Volume: 13 Issue: 2
Author(s): Pritish Nilendu, Sayantani Roychoudhary, Karishma Deshpande and Nilesh K. Sharma*
Affiliation:
- Cancer and Translational Research Lab, Dr. D.Y. Patil Biotechnology & Bioinformatics Institute, Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra,India
Keywords: Cellular growth, cancer, proteomics, protein, regulation, signaling pathway, targeted therapy.
Abstract: Background: Currently, existing regimens of genotoxic drugs have been suggested to be complemented with molecular inhibitors as combinatorial and cocktail approaches in malignancy.
Methods: In the last decade, attempts have been reported to test several new class of anticancer drug such as miRNA mimetics, RNA enzymes, small molecular inhibitors, DNA repair protein inhibitors and peptide mimetics.
Results: With the advent of rapidly growing genomic, epigenomic and proteomic data, design and application of peptide mimetics appear to thrive and sustain for an impactful cancer therapy. However, certain bottlenecks are envitable such as delivery of peptide mimetics drug in clinical settings, reducing the side effects, immune responses and pharmacokinetic properties.
Conclusion: This review discusses emerging issues and potential avenues related to the scope and limitations of peptide mimetics in cancer treatment.
Export Options
About this article
Cite this article as:
Nilendu Pritish, Roychoudhary Sayantani , Deshpande Karishma and Sharma K. Nilesh *, Therapeutic Peptide Mimetics Looking for a Turn to Block Aberrant Players of Malignancy, Current Cancer Therapy Reviews 2017; 13 (2) . https://dx.doi.org/10.2174/1573394713666170615115259
DOI https://dx.doi.org/10.2174/1573394713666170615115259 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
Call for Papers in Thematic Issues
Advancements in Lipid Nanoparticle Delivery Systems for mRNA Therapeutics
The thematic issue will focus on key areas such as lipid nanoparticles, mRNA therapeutics, drug delivery systems, nanotechnology in medicine, targeted therapy, non-viral vectors, precision medicine, and biomedical engineering.read more
Current progress in Protein Degradation and Cancer Therapy
argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Light Directed Gene Transfer by Photochemical Internalisation
Current Gene Therapy Involvement of Targeting and Scaffolding Proteins in the Regulation of the EGFR/Ras/MAPK Pathway in Oncogenesis
Current Signal Transduction Therapy The Biological Functions of NF-κB1 (p ) and its Potential as an Anti-Cancer Target
Current Cancer Drug Targets Anti-VEGF Anticancer Drugs: Mind the Hypertension
Recent Advances in Cardiovascular Drug Discovery (Discontinued) VEGF in Tumor Progression and Targeted Therapy
Current Cancer Drug Targets Novel Marine-Derived Anti-Cancer Agents
Current Pharmaceutical Design Targeting Synthetic Lethality in DNA Damage Repair Pathways as an Anti-Cancer Strategy
Current Drug Targets Perspectives of Benzimidazole Derivatives as Anticancer Agents in the New Era
Anti-Cancer Agents in Medicinal Chemistry The Bacterial lux Reporter System: Applications in Bacterial Localisation Studies
Current Gene Therapy Subject Index to Volume 3
Current Medicinal Chemistry - Central Nervous System Agents Importance of ABC Transporters in Drug Development
Current Pharmaceutical Design Kisspeptin: Paving the Way to a New Therapeutic Avenue in Reproduction
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Glycogen Synthase Kinase 3 as an Anticancer Drug Target: Novel Experimental Findings and Trends in the Design of Inhibitors
Current Pharmaceutical Design Biological Function and Medicinal Research Significance of G-Quadruplex Interactive Proteins
Current Topics in Medicinal Chemistry Inhibition of Aurora A Kinase by Alisertib Induces Autophagy and Cell Cycle Arrest and Increases Chemosensitivity in Human Hepatocellular Carcinoma HepG2 Cells
Current Cancer Drug Targets Cancer Therapy: Targeting Cell Cycle Regulators
Anti-Cancer Agents in Medicinal Chemistry Inhibitors of HDACs - Effective Drugs Against Cancer?
Current Cancer Drug Targets Current Innovations in Laparoscopy
Current Women`s Health Reviews An Up-date of Olive Oil Phenols in Inflammation and Cancer: Molecular Mechanisms and Clinical Implications
Current Medicinal Chemistry Oral Precancerous Lesions Show Increased Levels of Glutathione Compared to Cancerous Tissue
Current Nutrition & Food Science