Revisiting Antipsychotic-induced Akathisia: Current Issues and Prospective Challenges

Author(s): Haitham Salem, Caesa Nagpal, Teresa Pigott, Antonio Lucio Teixeira*

Journal Name: Current Neuropharmacology

Volume 15 , Issue 5 , 2017

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Graphical Abstract:


Background: Akathisia continues to be a significant challenge in current neurological and psychiatric practice. Prompt and accurate detection is often difficult and there is a lack of consensus concerning the neurobiological basis of akathisia. No definitive treatment has been established for akathisia despite numerous preclinical and clinical studies.]

Method: We reviewed antipsychotic-induced akathisia including its clinical presentation, proposed underlying pathophysiology, current and under investigation therapeutic strategies.

Conclusion: Despite the initial promise that second generation antipsychotics would be devoid of akathisia effects, this has not been confirmed. Currently, there are limited therapeutic options for the clinical practice and the evidence supporting the most widely used treatments (beta blockers, anticholinergic drugs) is still absent or inconsistent.

Keywords: Akathisia, antipsychotics, neuroleptics, movement disorders, agitation, anticholinergics, benzodiazepines, extrapyramidal signs.

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Article Details

Year: 2017
Published on: 14 June, 2017
Page: [789 - 798]
Pages: 10
DOI: 10.2174/1570159X14666161208153644
Price: $65

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