Abstract
Targeting of MMP-9 could be a useful approach for anticancer therapy. The inhibitory activities of 23 flavonoids on tumor necrosis factors alpha (TNF)-induced matrix metalloproteinases 9 (MMP-9) gene expression were analyzed quantitatively. To elucidate the relationships between the structural properties of flavonoids and their inhibitory activities, comparative molecular field analysis and comparative molecular similarity indices analysis were carried out. The structural conditions required for high inhibitory activity towards TNF-induced MMP-9 gene expression were derived. In addition, for spiraeoside, which showed the best activity among the test compounds, reverse transcription polymerase chain reaction (PCR), real-time PCR analysis, and promoter-reporter assay were performed. Spiraeoside could be a lead compound for the anticancer agents.
Keywords: Matrix metallopeptidase 9, CoMFA, CoMSIA, flavonoid, spiraeoside.
Letters in Drug Design & Discovery
Title:Relationships Between the Structural Properties of Flavonoids and their Inhibitory Activities Against Matrix Metallopeptidase 9
Volume: 14 Issue: 1
Author(s): Soon Young Shin, Hyeryoung Jung, Yearam Jung, Beom Soo Kim, Young Han Lee and Yoongho Lim
Affiliation:
Keywords: Matrix metallopeptidase 9, CoMFA, CoMSIA, flavonoid, spiraeoside.
Abstract: Targeting of MMP-9 could be a useful approach for anticancer therapy. The inhibitory activities of 23 flavonoids on tumor necrosis factors alpha (TNF)-induced matrix metalloproteinases 9 (MMP-9) gene expression were analyzed quantitatively. To elucidate the relationships between the structural properties of flavonoids and their inhibitory activities, comparative molecular field analysis and comparative molecular similarity indices analysis were carried out. The structural conditions required for high inhibitory activity towards TNF-induced MMP-9 gene expression were derived. In addition, for spiraeoside, which showed the best activity among the test compounds, reverse transcription polymerase chain reaction (PCR), real-time PCR analysis, and promoter-reporter assay were performed. Spiraeoside could be a lead compound for the anticancer agents.
Export Options
About this article
Cite this article as:
Shin Young Soon, Jung Hyeryoung, Jung Yearam, Kim Soo Beom, Lee Han Young and Lim Yoongho, Relationships Between the Structural Properties of Flavonoids and their Inhibitory Activities Against Matrix Metallopeptidase 9, Letters in Drug Design & Discovery 2017; 14 (1) . https://dx.doi.org/10.2174/1570180813666160919161434
DOI https://dx.doi.org/10.2174/1570180813666160919161434 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Use of Fas Ligand, TRAIL and Bax in Gene Therapy of Prostate Cancer
Current Gene Therapy Early-Life Stress and Psychiatric Disorders: Epidemiology, Neurobiology and Innovative Pharmacological Targets
Current Pharmaceutical Design A Review on Chemical Profile of Coumarins and their Therapeutic Role in the Treatment of Cancer
Current Drug Delivery Apoptosis is a Critical Cellular Event in Cancer Chemoprevention and Chemotherapy by Selenium Compounds
Current Cancer Drug Targets A Comprehensive Review on SAR of Curcumin
Mini-Reviews in Medicinal Chemistry Nutraceuticals and their Derived Nano-Formulations for the Prevention and Treatment of Alzheimer's Disease
Current Molecular Pharmacology Oleic Acid Protects Against Oxidative Stress Exacerbated by Cytarabine and Doxorubicin in Rat Brain
Anti-Cancer Agents in Medicinal Chemistry Genistein Inhibits Cell Growth and Invasion Through Regulation of miR-27a in Pancreatic Cancer Cells
Current Pharmaceutical Design Integrin αvβ3 as a Therapeutic Target for Blocking Tumor-Induced Angiogenesis
Current Drug Targets Clinical Pharmacokinetics of Systemically Administered Antimycotics
Current Clinical Pharmacology The Role of Microbiota and Intestinal Permeability in the Pathophysiology of Autoimmune and Neuroimmune Processes with an Emphasis on Inflammatory Bowel Disease Type 1 Diabetes and Chronic Fatigue Syndrome
Current Pharmaceutical Design Actions of Melatonin, Its Structural and Functional Analogs in the Central Nervous System and the Significance of Metabolism
Central Nervous System Agents in Medicinal Chemistry Editorial [Hot topic: Focal Adhesion Kinase Signaling in Cancer- Part II (Guest Editor: Vita M. Golubovskaya)]
Anti-Cancer Agents in Medicinal Chemistry Recent Advances in the Development of Multi-Kinase Inhibitors
Mini-Reviews in Medicinal Chemistry CXCL3 is a Potential Target for Breast Cancer Metastasis
Current Cancer Drug Targets Drug Delivery Nanoparticles in Treating Chemoresistant Tumor Cells
Current Medicinal Chemistry Polymers and Biopolymers as Drug Delivery Systems in Nanomedicine
Recent Patents on Nanomedicine A Review of the Evidence for a Neuroendocrine Link Between Stress, Depression and Diabetes Mellitus
Current Diabetes Reviews The Role of Tregs in Cancer: Foxp3 as a Putative Target for Therapy
Current Signal Transduction Therapy Colchicine: An Ancient Drug with Multiple Benefits
Current Pharmaceutical Design