Title:Synthesis, Characterization, and Atenolol Delivery Application of Functionalized Mesoporous Hydroxyapatite Nanoparticles Prepared by Microwave-Assisted Co-precipitation Method
VOLUME: 13 ISSUE: 7
Author(s):Sobhan Mortazavi-Derazkola, Mohammad Reza Naimi-Jamal and Seyedeh Masoumeh Ghoreishi
Affiliation:Research Laboratory of Green Organic Synthesis & Polymers, Department of Chemistry, Iran University of Science and Technology, Naarmak, Farjaam Street, 16846-13114 Tehran, Iran.
Keywords:Atenolol, drug release, mesoporous hydroxyapatite nanoparticles, microwave-assisted co-precipitation, MPTS.
Abstract:Background: Atenolol has been used to treat angina and hypertension,
either alone or with other antihypertensives. Despite its usefulness, it shows some
side effects such as diarrhea and nausea in some patients. A method for slow release
of atenolol in intestine is helpful to prevent such side effects.
Methods: A facile co-precipitation microwave-assisted method was used to fabricate
mesoporous hydroxyapatite nanoparticles (mHAp). It was then functionalized to
have SO3H groups. The synthesized material was used for storage/slow release study
of atenolol.
Results: Atenolol loaded mHAp shows immediate release of atenolol in pH 8,
whileafter functionalizing shows up to ca. 30% release at the beginning. In pH 1, 50% of drug was
released after 10 h from AT@mHAp and after 18h the drug was almost completely released.The drug
release profiles of functionalized HAp at pH value 1 and 8reveals the complete release of atenolol in intestine
pH, while no complete release is observed in stomach environment.
Conclusion: The aims of this work were synthesis and characterization of mesoporous HAp through the
microwave-assisted co-precipitation method and elucidate the underlying drug release capability of
mesoporous HAp nanoparticles. The SO3H group was incorporated into the mesoporous HAp and then
used as drug delivery carriers using atenolol as a model drug to investigate their drug storage/release
properties in simulated body fluid (SBF). Increasing pH value to 8 causes increase in the drug release.
