Epidemiological studies associate obesity with onset of asthma, especially in
obese children, suggesting obesity as the risk factor for asthma. Obesity-induced chronic
inflammation has been implicated in the lung inflammation, yet specific mediators and
mechanisms are lacking. Obesity is associated with increased expression of 5-lipoxygenase
(5-LO) pathway and increased Leukotrienes (LTs) production has been observed in obese
asthma patients. However, the precise mechanism that predisposes lungs inflammation in obese is not clearly
understood. This article discusses the production and regulation of LTs in obese individuals and presents
probable mechanisms regarding the role of LTs in lung inflammation that may lead to obesity-induced asthma.
Leukotrienes are well known mediators of asthma but their role in obesity-induced asthma is not clearly
understood and thus needs further research. Since efficient antagonists and inhibitors of 5-LO pathways are
known, understanding of molecular mechanism of LTs, especially Cysteinyl-LTs, in obesity-induced asthma
could lead to optimal treatment regimens for the prevention and treatment of asthma in obese individuals.
Keywords: Adipokines, asthma, cysteinyl leukotrienes, lung inflammation, obesity.
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