Abstract
Accumulating evidence indicates that low grade inflammation is closely associated with obesity-related disorders including type 2 diabetes, hypertension and atherosclerosis. Adiponectin is a fat-derived plasma protein with anti-inflammatory functions. Circulating levels of adiponectin are decreased in obese states, and these conditions are broadly associated with various obesity-related diseases. Furthermore, adiponectin has direct protective functions against cardiovascular disease, cerebrovascular disease, non-alcoholic steatohepatitis (NASH) and chronic kidney disease (CKD). In this review, we will focus on the protective functions of adiponectin against these obesity-related diseases from the view point of its anti-inflammatory properties.
Keywords: Adiponectin, cardiovascular disease, cerebrovascular disease, CKD, inflammation, insulin resistance, NASH.
Endocrine, Metabolic & Immune Disorders - Drug Targets
Title:Adiponectin as a Target in Obesity-related Inflammatory State
Volume: 15 Issue: 2
Author(s): Koji Ohashi, Daisuke Yuasa, Rei Shibata, Toyoaki Murohara and Noriyuki Ouchi
Affiliation:
Keywords: Adiponectin, cardiovascular disease, cerebrovascular disease, CKD, inflammation, insulin resistance, NASH.
Abstract: Accumulating evidence indicates that low grade inflammation is closely associated with obesity-related disorders including type 2 diabetes, hypertension and atherosclerosis. Adiponectin is a fat-derived plasma protein with anti-inflammatory functions. Circulating levels of adiponectin are decreased in obese states, and these conditions are broadly associated with various obesity-related diseases. Furthermore, adiponectin has direct protective functions against cardiovascular disease, cerebrovascular disease, non-alcoholic steatohepatitis (NASH) and chronic kidney disease (CKD). In this review, we will focus on the protective functions of adiponectin against these obesity-related diseases from the view point of its anti-inflammatory properties.
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Cite this article as:
Ohashi Koji, Yuasa Daisuke, Shibata Rei, Murohara Toyoaki and Ouchi Noriyuki, Adiponectin as a Target in Obesity-related Inflammatory State, Endocrine, Metabolic & Immune Disorders - Drug Targets 2015; 15 (2) . https://dx.doi.org/10.2174/1871530315666150316122709
DOI https://dx.doi.org/10.2174/1871530315666150316122709 |
Print ISSN 1871-5303 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3873 |
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