The Functions of F-box Proteins in Regulating the Epithelial to Mesenchymal Transition

Author(s): Jingna Su, Xuyuan Yin, Xiuxia Zhou, Wenyi Wei, Zhiwei Wang

Journal Name: Current Pharmaceutical Design

Volume 21 , Issue 10 , 2015

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Epithelial to mesenchymal transition (EMT) has been unraveled to regulate the tumor invasion and metastasis processes. In this review, in order to better understand the regulatory mechanisms of EMT, we describe that F-box pr oteins could be critically involved in regulating the EMT process in human cancers. Specifically, we discuss how th ese F-box proteins directly control the stability of EMT regulators such as E-cadherin, β-catenin, Twist, Slug, Snail and ZEB. Moreover, we summary mechanistically how the F-box proteins govern EMT progression through regulation of EMT inducers including Notch, NF-κB, Akt, Hedgehog, mTOR, and HIF-1α. Therefore, targeting these F-box proteins could be useful for treating human cancers.

Keywords: Cancer, degradation, E3 ligases, EMT, ubiquitin.

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Article Details

Year: 2015
Page: [1311 - 1317]
Pages: 7
DOI: 10.2174/1381612821666141211144203
Price: $65

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