Synthesis and Biochemical Evaluation of a Range of 4-(n-alkanesulfonate) benzyl Imidazole-Based Compounds as Inhibitors of Rat Testicular 17α-hydroxylase/17,20-lyase (P450_17α) in the Treatment of Hormone- Dependent Prostate Cancer

Title:Synthesis and Biochemical Evaluation of a Range of 4-(n-alkanesulfonate) benzyl Imidazole-Based Compounds as Inhibitors of Rat Testicular 17α-hydroxylase/17,20-lyase (P450_17α) in the Treatment of Hormone- Dependent Prostate Cancer

VOLUME: 11 ISSUE: 8

Author(s):Pallav S. Shah, Imran Shahid, Wai-Yee Lee, Caroline P. Owen and Sabbir Ahmed

Affiliation:Institute of Biomedical and Environmental Health Research (IBEHR), School of Science, Faculty of Science and Technology, University of the West of Scotland, Paisley, Renfrewshire, Scotland, PA1 2BE, UK.

Keywords:17α-hydroxylase/17, 17α-OHase, 20-lyase, Azole, Inhibitors Lyase.

Abstract:17α-Hydroxylase/17,20-lyase is a target in the treatment of hormone-dependent prostate cancer. Here we report the results of a study into a range of alkanesulfonate derivatives of 4-hydroxybenzylimidazole which show the compounds to be good inhibitors with 5 [IC₅₀=1.11µM (17α-OHase) and IC₅₀=1.28µM (lyase)] being the most potent but weaker than ketoconazole.

Cite this article as:

Pallav S. Shah, Imran Shahid, Wai-Yee Lee, Caroline P. Owen and Sabbir Ahmed, “Synthesis and Biochemical Evaluation of a Range of 4-(n-alkanesulfonate) benzyl Imidazole-Based Compounds as Inhibitors of Rat Testicular 17α-hydroxylase/17,20-lyase (P450_17α) in the Treatment of Hormone- Dependent Prostate Cancer”, Letters in Drug Design & Discovery (2014) 11: 1000. https://doi.org/10.2174/1570180811666131230235538

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