Abstract
ROS, including .OH, is now recognized as the hallmark of inflammation and damage to the anti-proteinase barrier has been implicated in a number of pathophysiological conditions. We have previously shown that O2 .- and H2O2/HOCl are physiologically relevant inactivators of α2M, a key anti-proteinase. Here, we show that .OH disrupted caprine α2M structure and antiproteolytic potential in vitro, suggesting that its function could be compromised via oxidative modification.
Keywords: Caprine, alpha-2-macroglobulin, hydroxyl radical
Protein & Peptide Letters
Title: Hydroxyl Radical Mediates Oxidative Modification of Caprine Alpha-2 Macroglobulin
Volume: 16 Issue: 1
Author(s): Shakil A. Khan and Fahim H. Khan
Affiliation:
Keywords: Caprine, alpha-2-macroglobulin, hydroxyl radical
Abstract: ROS, including .OH, is now recognized as the hallmark of inflammation and damage to the anti-proteinase barrier has been implicated in a number of pathophysiological conditions. We have previously shown that O2 .- and H2O2/HOCl are physiologically relevant inactivators of α2M, a key anti-proteinase. Here, we show that .OH disrupted caprine α2M structure and antiproteolytic potential in vitro, suggesting that its function could be compromised via oxidative modification.
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Cite this article as:
Khan A. Shakil and Khan H. Fahim, Hydroxyl Radical Mediates Oxidative Modification of Caprine Alpha-2 Macroglobulin, Protein & Peptide Letters 2009; 16 (1) . https://dx.doi.org/10.2174/092986609787049376
DOI https://dx.doi.org/10.2174/092986609787049376 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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