Abstract
The medicinal properties of garlic (Allium sativum) have been well known and widely used since historical times. Garlic compounds have received increasing attention during the last few years due to their cancer chemopreventive properties. The anti-cancer activity of garlic-derived organosulfur compounds (OSCs) are extensively reported in many cancers but only a few in the pediatric tumor neuroblastoma, which warrants exploration of new therapy for its management. There are some recent reports suggesting that garlicderived OSCs cause cell cycle arrest, generate reactive oxygen species (ROS), activate stress kinases, and also stimulate the mitochondrial pathway for apoptosis in malignant neuroblastoma. The comprehensive mechanisms of anti-cancer action of OSCs still remain unclear and require more studies in neuroblastoma. This review is designed to highlight the known molecular mechanisms of anti-cancer actions of garlic-derived OSCs in neuroblastoma and as well as in several other cancers. Further studies should be conducted to establish the clinical expediency of garlic-derived OSCs for treatment of malignant neuroblastoma in humans.
Keywords: Apoptosis, caspases, calpain, diallyl sufide, diallyl disulfide, neuroblastoma, stem cell transplantation, high-risk neuroblastomas, DNA fragmentation, pro-apoptotic molecules, DNase (ICAD), Apoptosis-inducing factor (AIF), phytochemicals
Anti-Cancer Agents in Medicinal Chemistry
Title: Molecular Mechanisms of Anti-cancer Action of Garlic Compounds in Neuroblastoma
Volume: 11 Issue: 4
Author(s): Surajit Karmakar, Subhasree Roy Choudhury, Naren L. Banik and Swapan K. Ray
Affiliation:
Keywords: Apoptosis, caspases, calpain, diallyl sufide, diallyl disulfide, neuroblastoma, stem cell transplantation, high-risk neuroblastomas, DNA fragmentation, pro-apoptotic molecules, DNase (ICAD), Apoptosis-inducing factor (AIF), phytochemicals
Abstract: The medicinal properties of garlic (Allium sativum) have been well known and widely used since historical times. Garlic compounds have received increasing attention during the last few years due to their cancer chemopreventive properties. The anti-cancer activity of garlic-derived organosulfur compounds (OSCs) are extensively reported in many cancers but only a few in the pediatric tumor neuroblastoma, which warrants exploration of new therapy for its management. There are some recent reports suggesting that garlicderived OSCs cause cell cycle arrest, generate reactive oxygen species (ROS), activate stress kinases, and also stimulate the mitochondrial pathway for apoptosis in malignant neuroblastoma. The comprehensive mechanisms of anti-cancer action of OSCs still remain unclear and require more studies in neuroblastoma. This review is designed to highlight the known molecular mechanisms of anti-cancer actions of garlic-derived OSCs in neuroblastoma and as well as in several other cancers. Further studies should be conducted to establish the clinical expediency of garlic-derived OSCs for treatment of malignant neuroblastoma in humans.
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Cite this article as:
Karmakar Surajit, Roy Choudhury Subhasree, L. Banik Naren and K. Ray Swapan, Molecular Mechanisms of Anti-cancer Action of Garlic Compounds in Neuroblastoma, Anti-Cancer Agents in Medicinal Chemistry 2011; 11 (4) . https://dx.doi.org/10.2174/187152011795677553
DOI https://dx.doi.org/10.2174/187152011795677553 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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