Abstract
The formulation and fabrication methods for several types of tissue engineering scaffolds with drug delivery capabilities are presented in this review. Tissue engineered constructs are temporary substitutes developed to treat damaged or lost tissue. One key component of such constructs is scaffolds that are often developed to mimic the extra cellular matrix (ECM). As natural ECM contains biomolecules to support proper growth and function of cells, inclusion of these biomolecular cues have been shown to be necessary for proper cell growth and function in tissue engineering. Thus, an effective tissue engineering scaffold should provide such biomolecular cues. This can be achieved through drug delivery in scaffolds. Studies have shown that drug delivery systems are necessary to protect drugs, and provide sustained drug release that is often needed for effective therapy. The tissue engineering features of 4 scaffold types are described, including films, hydrogels, fibers, and microspheres/nanospheres. Fabrication techniques and drug encapsulation methods for these scaffolds are reviewed in addition to some observations arising from the use of these techniques and methods.
Keywords: Drug delivery, tissue engineering scaffold, film, hydrogel, fiber, microsphere, nanosphere
Current Pharmaceutical Design
Title: Fabricating Tissue Engineering Scaffolds for Simultaneous Cell Growth and Drug Delivery
Volume: 16 Issue: 21
Author(s): Wenhui Chen, Yasuhiko Tabata and Yen Wah Tong
Affiliation:
Keywords: Drug delivery, tissue engineering scaffold, film, hydrogel, fiber, microsphere, nanosphere
Abstract: The formulation and fabrication methods for several types of tissue engineering scaffolds with drug delivery capabilities are presented in this review. Tissue engineered constructs are temporary substitutes developed to treat damaged or lost tissue. One key component of such constructs is scaffolds that are often developed to mimic the extra cellular matrix (ECM). As natural ECM contains biomolecules to support proper growth and function of cells, inclusion of these biomolecular cues have been shown to be necessary for proper cell growth and function in tissue engineering. Thus, an effective tissue engineering scaffold should provide such biomolecular cues. This can be achieved through drug delivery in scaffolds. Studies have shown that drug delivery systems are necessary to protect drugs, and provide sustained drug release that is often needed for effective therapy. The tissue engineering features of 4 scaffold types are described, including films, hydrogels, fibers, and microspheres/nanospheres. Fabrication techniques and drug encapsulation methods for these scaffolds are reviewed in addition to some observations arising from the use of these techniques and methods.
Export Options
About this article
Cite this article as:
Chen Wenhui, Tabata Yasuhiko and Wah Tong Yen, Fabricating Tissue Engineering Scaffolds for Simultaneous Cell Growth and Drug Delivery, Current Pharmaceutical Design 2010; 16 (21) . https://dx.doi.org/10.2174/138161210791920478
DOI https://dx.doi.org/10.2174/138161210791920478 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Pharmacological Innovations for Posttraumatic Stress Disorder and Medication- Enhanced Psychotherapy
Current Pharmaceutical Design Motor and Sensory Dysfunction in Musician's Dystonia
Current Neuropharmacology The Valsalva Maneuver and Alzheimers Disease: Is there a link?
Current Alzheimer Research Nanoceria: A Novel Cytoprotective Drug Delivery Carrier
Current Nanomedicine How Does Pain Induce Negative Emotion? Role of the Bed Nucleus of the Stria Terminalis in Pain-Induced Place Aversion
Current Molecular Medicine Cannabinoids
Current Drug Targets - CNS & Neurological Disorders Double-Blind, Placebo-Controlled, Randomized Phase I/IIa Study (Safety and Efficacy) with Buspirone/Levodopa/Carbidopa (SpinalonTM) in Subjects with Complete AIS A or Motor-Complete AIS B Spinal Cord Injury
Current Pharmaceutical Design Phylogenetic Aspects of Nucleobindin-2/Nesfatin-1
Current Pharmaceutical Design Histological Alterations in the Testicular Tissue Induced by Sildenafil Overdoses
Drug Metabolism Letters Gels and Jellies as a Dosage Form for Dysphagia Patients: A Review
Current Drug Therapy Structural and Functional Studies of Galectin-1: A Novel Axonal Regeneration-Promoting Activity for Oxidized Galectin-1
Current Drug Targets Patent Selections
Recent Patents on CNS Drug Discovery (Discontinued) Resuscitation of the Newborn in the Delivery Room
Current Pediatric Reviews Novel Penetrating Cations for Targeting Mitochondria
Current Pharmaceutical Design Neutralizing Endogenous VEGF Following Traumatic Spinal Cord Injury Modulates Microvascular Plasticity but not Tissue Sparing or Functional Recovery
Current Neurovascular Research On the Future Development of Optimally-Sized Lipid-Insoluble Systemic Therapies for CNS Solid Tumors and Other Neuropathologies
Recent Patents on CNS Drug Discovery (Discontinued) Exploring the Mitochondrial Apoptotic Cell Death Landscape and Associated Components Serving as Molecular Targets, Primarily for Synthetic and Natural Drugs Targeting Oncology Therapeutics
Current Molecular Pharmacology Role of PACAP in Neural Stem/Progenitor Cell and Astrocyte: from Neural Development to Neural Repair
Current Pharmaceutical Design The Many Roles of Chemokine Receptors in Neurodegenerative Disorders: Emerging New Therapeutical Strategies
Current Medicinal Chemistry Minocycline and Cytoprotection: Shedding New Light on a Shadowy Controversy
Current Drug Delivery