Abstract
Ribozymes are involved in strategies to block gene expression and have been used as agents against viral infections and cancer. Emphasis has been on studies using hairpin and hammerhead ribozymes. The uniqueness of ribozymes is that they posses multiple turnover allowing high efficiency as antiviral agents. Ribozymes have been directed to human immunodeficiency virus (HIV), hepatitis (B, C and E) and human papillomavirus (HPV), the cause of cervical cancer. The mode of action of antiviral ribozymes, their structure and their in vitro effectiveness as inhibitors of HIV, HBV, HCV, HEV and HPV is reviewed. Although ribozymes have been demonstrated as effective antivirals in cell culture and some animal models, clinical studies have been limited. Nevertheless, ribozymes remain as a viable alternative to antisense and RNA interference
Keywords: Ribozyme, catalytic RNA, antisense, ribonucleic acid, RNA, papillomavirus, AIDS, hepatitis virus, hepadnavirus, HIV, HPV
Letters in Drug Design & Discovery
Title: Utilization of Ribozymes as Antiviral Agents
Volume: 3 Issue: 6
Author(s): M. L. Benitez-Hess and L. M. Alvarez-Salas
Affiliation:
Keywords: Ribozyme, catalytic RNA, antisense, ribonucleic acid, RNA, papillomavirus, AIDS, hepatitis virus, hepadnavirus, HIV, HPV
Abstract: Ribozymes are involved in strategies to block gene expression and have been used as agents against viral infections and cancer. Emphasis has been on studies using hairpin and hammerhead ribozymes. The uniqueness of ribozymes is that they posses multiple turnover allowing high efficiency as antiviral agents. Ribozymes have been directed to human immunodeficiency virus (HIV), hepatitis (B, C and E) and human papillomavirus (HPV), the cause of cervical cancer. The mode of action of antiviral ribozymes, their structure and their in vitro effectiveness as inhibitors of HIV, HBV, HCV, HEV and HPV is reviewed. Although ribozymes have been demonstrated as effective antivirals in cell culture and some animal models, clinical studies have been limited. Nevertheless, ribozymes remain as a viable alternative to antisense and RNA interference
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Cite this article as:
Benitez-Hess L. M. and Alvarez-Salas M. L., Utilization of Ribozymes as Antiviral Agents, Letters in Drug Design & Discovery 2006; 3 (6) . https://dx.doi.org/10.2174/157018006777805521
DOI https://dx.doi.org/10.2174/157018006777805521 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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