Abstract
The use of multicomponent reactions as potential synthetic processes, ionic liquids as catalysts and water as reaction medium is a suitable approach that respects, in some extent, the requirements of sustainable chemistry. In this context, we report, herein, an efficient and high yielding four-component synthesis of 6-amino-4-aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles involving ethyl acetoacetate, hydrazine hydrate, malononitrile, and various aromatic aldehydes using octyltriphenylphosphonium bromide as an effective and recoverable catalyst and water as solvent under mild reaction conditions.
Keywords: Aqueous medium, ionic liquid, multicomponent reactions, octyltriphenylphosphonium bromide, pyranopyrazoles, rate enhancement, triphenylphosphine.
Letters in Organic Chemistry
Title:An Efficient Organocatalyst for Environmentally benign Synthesis of Pyranopyrazole Derivatives in Aqueous Medium
Volume: 12 Issue: 10
Author(s): Faiza Boukezzoula, Taoues Boumoud, Boudjemaa Boumoud and Abdelmadjid Debache
Affiliation:
Keywords: Aqueous medium, ionic liquid, multicomponent reactions, octyltriphenylphosphonium bromide, pyranopyrazoles, rate enhancement, triphenylphosphine.
Abstract: The use of multicomponent reactions as potential synthetic processes, ionic liquids as catalysts and water as reaction medium is a suitable approach that respects, in some extent, the requirements of sustainable chemistry. In this context, we report, herein, an efficient and high yielding four-component synthesis of 6-amino-4-aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles involving ethyl acetoacetate, hydrazine hydrate, malononitrile, and various aromatic aldehydes using octyltriphenylphosphonium bromide as an effective and recoverable catalyst and water as solvent under mild reaction conditions.
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Cite this article as:
Boukezzoula Faiza, Boumoud Taoues, Boumoud Boudjemaa and Debache Abdelmadjid, An Efficient Organocatalyst for Environmentally benign Synthesis of Pyranopyrazole Derivatives in Aqueous Medium, Letters in Organic Chemistry 2015; 12 (10) . https://dx.doi.org/10.2174/1570178612666150924001127
DOI https://dx.doi.org/10.2174/1570178612666150924001127 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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