Abstract
Terpenoids and especially triterpenoids are the largest and the most diverse group of naturally occurring organic compounds. Its diversity plays very important role in new chemical entities activity screening against different disorders. Some of these compounds and their semi-synthetic derivatives can be identified as potential therapeutics against neurodegenerative diseases and were widely studied in the last few years. Celastrol, oleanolic acid, ursolic acid, asiatic acid, erythrodiol, and some triterpenoid saponins have the ability to protect the brain against neurodegenerative and neuroinflammatory processes. This review article is focused on triterpenoids as possible drugs to treat or slow the progression of neurodegenerative diseases such as Parkinson’s disease (PD), Alzheimer’s Disease (AD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS).
Keywords: Triterpenoids, neurodegeneration, celastrol, neuroinflammation, natural terpenoids, pharmacology, dementia, animal models, HIV-encephalopathy.
Mini-Reviews in Organic Chemistry
Title:Natural Triterpenoids and their Derivatives with Pharmacological Activity Against Neurodegenerative Disorders
Volume: 11 Issue: 3
Author(s): Piotr Ruszkowski and Teresa Bobkiewicz-Kozlowska
Affiliation:
Keywords: Triterpenoids, neurodegeneration, celastrol, neuroinflammation, natural terpenoids, pharmacology, dementia, animal models, HIV-encephalopathy.
Abstract: Terpenoids and especially triterpenoids are the largest and the most diverse group of naturally occurring organic compounds. Its diversity plays very important role in new chemical entities activity screening against different disorders. Some of these compounds and their semi-synthetic derivatives can be identified as potential therapeutics against neurodegenerative diseases and were widely studied in the last few years. Celastrol, oleanolic acid, ursolic acid, asiatic acid, erythrodiol, and some triterpenoid saponins have the ability to protect the brain against neurodegenerative and neuroinflammatory processes. This review article is focused on triterpenoids as possible drugs to treat or slow the progression of neurodegenerative diseases such as Parkinson’s disease (PD), Alzheimer’s Disease (AD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS).
Export Options
About this article
Cite this article as:
Ruszkowski Piotr and Bobkiewicz-Kozlowska Teresa, Natural Triterpenoids and their Derivatives with Pharmacological Activity Against Neurodegenerative Disorders, Mini-Reviews in Organic Chemistry 2014; 11 (3) . https://dx.doi.org/10.2174/1570193X1103140915111559
DOI https://dx.doi.org/10.2174/1570193X1103140915111559 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
Call for Papers in Thematic Issues
Applications of Molecular Descriptors in Physicochemical Properties Research of Organic Compounds
Chemical graph theory is concerned with all aspects of the application of graph theory to various areas of chemistry, including organic, theoretical, mathematical, and computational chemistry, as well as in bioinformatics and computational biology. By the use of the term chemical it is emphasized that one is allowed in chemical ...read more
Navigating the 2D Universe in Organic Chemistry
This special issue explores the transformative impact of two-dimensional (2D) materials on the realm of organic chemistry, unraveling new possibilities for synthesis, functionalization, and applications of organic compounds. Focused on the unique chemistry within this novel dimension, the issue highlights breakthroughs in the field of 2D organic chemistry. Contributions are ...read more
Small Molecules, Big Impact: Pioneering Approaches in Anti-inflammatory Care
This thematic issue is dedicated to the latest advancements and research breakthroughs in the realm of anti-inflammatory pharmacotherapy. With inflammation playing a critical role in numerous chronic conditions such as cardiovascular diseases, diabetes, and autoimmune disorders, there is an urgent need for more targeted, effective, and safer anti-inflammatory treatments. This ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Myxedema Heart Disease: A Rare Disease Entity: Case Report and Brief Review of the Literature
Current Hypertension Reviews Good at Heart: Preserving Cardiac Metabolism during aging
Current Diabetes Reviews Cellular Senescence in Cardiovascular Diseases: Potential Age-Related Mechanisms and Implications for Treatment
Current Pharmaceutical Design Gluten-dependent Intestinal Autoimmune Response
Current Pharmaceutical Design Myotonic Dystrophies 1 and 2: Complex Diseases with Complex Mechanisms
Current Genomics Modulation of Cardiac Metabolism During Myocardial Ischemia
Current Pharmaceutical Design Endogenous Retroelements in Cellular Senescence and Related Pathogenic Processes: Promising Drug Targets in Age-Related Diseases
Current Drug Targets The Role of Integrin-Mediated Cell Adhesion in Atherosclerosis: Pathophysiology and Clinical Opportunities
Current Pharmaceutical Design Treating Heart Failure with Preserved Ejection Fraction Related to Arterial Stiffness. Can we Kill Two Birds With One Stone?
Current Vascular Pharmacology subject Index To Volume 1
Current Molecular Medicine Association Between Hypothyroidism and Takotsubo Cardiomyopathy: Analysis of Nationwide Inpatient Sample Database
Reviews on Recent Clinical Trials GDF11 Attenuated ANG II-Induced Hypertrophic Cardiomyopathy and Expression of ANP, BNP and Beta-MHC Through Down- Regulating CCL11 in Mice
Current Molecular Medicine Smoking and Cardiovascular System: Cellular Features of the Damage
Current Pharmaceutical Design The Anti-fibrotic Hormone Relaxin is not Reno-protective, Despite Being Active, in an Experimental Model of Type 1 Diabetes
Protein & Peptide Letters Refining the Indications of Implantable Cardioverter Defibrillator in Patients with Left Ventricular Dysfunction
Reviews on Recent Clinical Trials Triple Threat: The Na+/Ca2+ Exchanger in the Pathophysiology of Cardiac Arrhythmia, Ischemia and Heart Failure
Current Drug Targets Cellular and Molecular Mechanisms of Low Cardiac Output Syndrome after Pediatric Cardiac Surgery
Current Vascular Pharmacology Aldose Reductase, Still a Compelling Target for Diabetic Neuropathy
Current Drug Targets Genetic Privacy in Sports: Clearing the Hurdles
Recent Patents on DNA & Gene Sequences Mutations of Mitochondrial DNA in Atherosclerosis and Atherosclerosis-Related Diseases
Current Pharmaceutical Design