Abstract
2'-Deoxy-methanocarba nucleosides are a class of compounds with important antiviral and antitumor activities. (N)-2'-deoxymethanocarbathymidine, (N)-MCT, is known as active and specific agent against herpes simplex viruses (HSV1 and 2) and Kaposi's sarcoma- associated herpes virus (KSHV). Some analogues such MRS2500 and MRS2279 have potent antithrombotic therapeutic effect due to their interactions with the purinergic P2Y1 receptors as antagonists, which have led to the new drug concepts. In the present review for the first time is provided a whole overview of the reported several synthetic approaches to the different analogues of 2'-deoxymethanocarba nucleosides as well as their biological activity.
Keywords: (N)-MCT, total synthesis, conformationally restricted nucleosides, antiviral, antitumor activities
Current Organic Synthesis
Title:Synthetic Survey and Activity of 2'-deoxy-methanocarba Nucleosides
Volume: 10 Issue: 2
Author(s): Krassimira P. Guerra and Carlos A. M. Afonso
Affiliation:
Keywords: (N)-MCT, total synthesis, conformationally restricted nucleosides, antiviral, antitumor activities
Abstract: 2'-Deoxy-methanocarba nucleosides are a class of compounds with important antiviral and antitumor activities. (N)-2'-deoxymethanocarbathymidine, (N)-MCT, is known as active and specific agent against herpes simplex viruses (HSV1 and 2) and Kaposi's sarcoma- associated herpes virus (KSHV). Some analogues such MRS2500 and MRS2279 have potent antithrombotic therapeutic effect due to their interactions with the purinergic P2Y1 receptors as antagonists, which have led to the new drug concepts. In the present review for the first time is provided a whole overview of the reported several synthetic approaches to the different analogues of 2'-deoxymethanocarba nucleosides as well as their biological activity.
Export Options
About this article
Cite this article as:
P. Guerra Krassimira and A. M. Afonso Carlos, Synthetic Survey and Activity of 2'-deoxy-methanocarba Nucleosides, Current Organic Synthesis 2013; 10 (2) . https://dx.doi.org/10.2174/1570179411310020002
DOI https://dx.doi.org/10.2174/1570179411310020002 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
Call for Papers in Thematic Issues
Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis
Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Papillary Thyroid Carcinoma in Pediatric Age: An Example of a Rare Tumour Managed Within a Cooperative Comprehensive Project
Current Pediatric Reviews Cytotoxicity and Target Modulation in Pediatric Solid Tumors by the Proteasome Inhibitor Carfilzomib
Current Cancer Drug Targets Detection of VEGF165 Using an Aptamer Affinity Probe in Microchip Capillary Electrophoresis
Current Pharmaceutical Analysis Cholinergic Targets in Lung Cancer
Current Pharmaceutical Design Tailored Angiogenesis Inhibition in Cancer Therapy: Respecting the Heart to Improve the Net Outcome
Current Signal Transduction Therapy Reversal of Bone Cancer Pain by HSV-1-Mediated Silencing of CNTF in an Afferent Area of the Spinal Cord Associated with AKT-ERK Signal Inhibition
Current Gene Therapy Effect of Liposomes with Different Double Arms Polyethyleneglycol on Hepatic Metastasis Model Mice and Evaluation Using a Fluorescent Imaging Device
Current Drug Delivery Therapeutic Use of Chemokines
Current Pharmaceutical Design Synergistic Enhancement of Cancer Therapy Using a Combination of Fusion Protein MG7-scFv/SEB and Tumor Necrosis Factor Alpha
Protein & Peptide Letters Angiogenesis and Vascularization of Uterine Leiomyoma: Clinical Value of Pseudocapsule Containing Peptides and Neurotransmitters
Current Protein & Peptide Science Nanoparticle Drug Delivery Systems: Recent Patents and Applications in Nanomedicine
Recent Patents on Nanomedicine Basic Mechanisms Involved in the Anti-Cancer Effects of Melatonin
Current Medicinal Chemistry Inhibition of Disulfide Reductases as a Therapeutic Strategy
Current Enzyme Inhibition Advances in Nanomedicine Towards Clinical Application in Oncology and Immunology
Current Pharmaceutical Biotechnology Synthesis and Altered Biodistribution of 99mTc Labeled Vincristine in Animal Model
Current Medical Imaging High Seroprevalence of Human Herpesvirus 8 Infection in HIV-positive Homosexual Men in Jiangsu Province, China
Current HIV Research Epidemiology and Pathology of Malignant Mesothelioma
Current Respiratory Medicine Reviews Structure Based Drug Design for HIV Protease: From Molecular Modeling to Cheminformatics
Current Topics in Medicinal Chemistry The Biological Role of mTOR in the Pathogenesis of Solid Tumors: An Overview
Current Enzyme Inhibition Opposing Functions for the Wilms Tumor Protein 1 (WT1) in Tumorigenesis
Current Pediatric Reviews