摘要
背景:有关多不饱和脂肪酸(PUFA)对人类健康影响的科学证据已经被积累。因此对于n-3 PUFAs可能会提高抗癌药物效率的假设开始了新的思考,n-6 PUFA的作用则需要更好地被评估。然而,PUFA的有效作用机制尚未完全阐明。这篇综述旨在报道关于n-6和n-3 PUFA在人类癌症发生和治疗中的作用的最新证明,重点关注PUFA发挥其作用的潜在机制。 方法:我们于2017年2月17日在PubMed进行了结构化搜索,用于2013年发表的同行评议研究文章。搜索语法为:PUFA或PUFAs和癌症。 结果:发现了矛盾的结果,最大的可能是由于遗传背景,不同饮食来源,不同营养素之间的相互作用以及肿瘤亚型。然而,最近的研究结果强烈支持在癌症预防和治疗中使用n-3 PUFAs。另一方面,即使最近它们的有益效果也被强调,n-6 PUFA通常与增加的癌症风险有关。 结论:N-3 PUFAs可能是一种潜在的治疗药物,有助于治疗至少某些类型的人类癌症。然而,仍需要更大样本量和更长随访时间的研究。为了增加关于食物和营养如何改善人类健康的知识,建议提供一个开放式的营养数据库。
关键词: 多不饱和脂肪酸,omega 3,omega 6,癌症,饮食,营养,人类健康
Current Medicinal Chemistry
Title:Recent Evidence on the Role of Dietary PUFAs in Cancer Development and Prevention
Volume: 25 Issue: 16
关键词: 多不饱和脂肪酸,omega 3,omega 6,癌症,饮食,营养,人类健康
摘要: Background: Scientific evidence has been accumulated about the effects of polyunsaturated fatty acids (PUFAs) on human health. The hypothesis that n-3 PUFAs might improve the efficiency of anticancer drugs has recently been considered. The role of n-6 PUFAs, in contrast, needs to be better assessed. However, the effective mechanisms of action of PUFAs have not been fully clarified yet. This review aims to report the most updated evidence on the role of n-6 and n-3 PUFAs in the development and treatment of human cancers, focusing on the potential mechanisms by which PUFAs exert their effects.
Methods: We undertook a structured search in PubMed on February 17th 2017 for peer-reviewed research articles published from 2013. The search syntax used was: PUFA or PUFAs and cancer.
Results: Contradictory results were found, most likely due to the genetic background, the different dietary sources used, the interaction among different nutrients, and the tumor subtypes. However, the more recent findings strongly support the use of n-3 PUFAs in cancer prevention and treatment. On the other hand, n-6 PUFAs are often associated with an increased risk of cancer, even if recently their beneficial effects have also been highlighted.
Conclusion: N-3 PUFAs may represent a potential therapeutic agent contributing to treat at least some type of human cancers. However, studies with larger sample sizes and longer follow-up times are still needed. To increase the knowledge about how food and nutrition can improve human health it is advisable to deliver an open access nutritional database.
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Cite this article as:
Recent Evidence on the Role of Dietary PUFAs in Cancer Development and Prevention, Current Medicinal Chemistry 2018; 25 (16) . https://dx.doi.org/10.2174/0929867325666171204160231
DOI https://dx.doi.org/10.2174/0929867325666171204160231 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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