摘要
蛙皮素/胃泌素释放肽(BN / GRP)一类生长因子在恶性肿瘤的增殖和进展中起着至关重要的作用。针对胃泌素释放肽信号抑制剂已开发和测试的抗癌化合物显示出有前景的临床前和早期阶段的临床结果。在这篇综述中,我们将讨论的分子信号,表达和在不同的肿瘤模型中蛙皮素/胃泌素释放肽-促胃液素释放肽受体的功能作用,并且会将重点放在现有的战略针对蛙皮素/胃泌素释放肽-促胃液素释放肽受体癌症治疗以及肿瘤的诊断和跟踪。
关键词: 肿瘤,神经肽,信号转导,药物靶标,临床试验。
Current Drug Targets
Title:Gastrin-Releasing Peptide Receptor Targeting in Cancer Treatment: Emerging Signaling Networks and Therapeutic Applications
Volume: 17 Issue: 5
Author(s): Mikko O. Laukkanen and Maria Domenica Castellone
Affiliation:
关键词: 肿瘤,神经肽,信号转导,药物靶标,临床试验。
摘要: Growth factors of the bombesin/gastrin releasing peptide (BN/GRP) family play a critical role in proliferation and progression of malignancies. Inhibitors targeting GRP signalling have been developed and tested as anticancer compounds showing promising preclinical and early phase clinical results. In this review, we will discuss the molecular signaling, expression and the functional role of BN/GRP-GRPR in different cancer models and will focus on the available strategies to target BN/GRP-GRPR in cancer treatment as well as in tumour diagnosis and follow up.
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Cite this article as:
Mikko O. Laukkanen and Maria Domenica Castellone , Gastrin-Releasing Peptide Receptor Targeting in Cancer Treatment: Emerging Signaling Networks and Therapeutic Applications, Current Drug Targets 2016; 17 (5) . https://dx.doi.org/10.2174/1389450116666151001112130
DOI https://dx.doi.org/10.2174/1389450116666151001112130 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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