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Current Drug Targets

Editor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Gastrin-Releasing Peptide Receptor Targeting in Cancer Treatment: Emerging Signaling Networks and Therapeutic Applications

Author(s): Mikko O. Laukkanen and Maria Domenica Castellone

Volume 17 , Issue 5 , 2016

Page: [508 - 514] Pages: 7

DOI: 10.2174/1389450116666151001112130

Price: $65

Abstract

Growth factors of the bombesin/gastrin releasing peptide (BN/GRP) family play a critical role in proliferation and progression of malignancies. Inhibitors targeting GRP signalling have been developed and tested as anticancer compounds showing promising preclinical and early phase clinical results. In this review, we will discuss the molecular signaling, expression and the functional role of BN/GRP-GRPR in different cancer models and will focus on the available strategies to target BN/GRP-GRPR in cancer treatment as well as in tumour diagnosis and follow up.

Keywords: Cancer, neuropeptide, signaling transduction, drug targets, clinical trial.

Graphical Abstract

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