The Prevalence of Shiga Toxin-1 in Non-Shigella Dysenteriae Isolates Collected from Diarrhea Samples in Patients, Ahvaz, Iran

Title:The Prevalence of Shiga Toxin-1 in Non-Shigella Dysenteriae Isolates Collected from Diarrhea Samples in Patients, Ahvaz, Iran

Volume: 21 Issue: 5

Author(s): Nahid Mahdian, Ebrahim Kouhsari, Ali Gheysarzadeh, Abbas Maleki, Hassan Valadbeigi and Nourkhoda Sadeghifard*

Affiliation:

• Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam,Iran

Keywords: Shigella species, shiga toxin, Stx1, S. flexneri, S. sonnei, S. boydii.

Abstract: Background: Acute diarrhea is a major public health problem, particularly in developing countries. Shigellosis is one of the substantial causative agents of microbial dysentery and still has a remarkable prevalence, particularly in areas with poor hygienic infrastructures. The probable existence of the deadly Shiga toxin (Stx) protein in some Shigella strains would manifest life-threatening clinical symptoms of the infection.

Methods: The aim of this study was to determine the presence of Shigella toxin 1 (Stx1) in isolated from patients with diarrhea. Totally, 227 Shigella species, including 60 S. flexneri, 157 S. sonnei, and 10 S. boydii were collected from diarrheal patients in the tropical infectious diseases research center of Ahvaz, Iran, during 2013-2015. The isolates were collected mostly from the intensive care unit, infectious disease, and surgery settings. The isolates were identified, and the polymerase chain reaction (PCR) was performed to detect the stx gene.

Results: The results indicated that none of them encode the stx1 gene.

Conclusion: Isolates of this study were not capable of stx1 encoding. Future investigations should consider the relations between other Shigella species and Shigella toxin in Iran.

Cite this article as:

Mahdian Nahid , Kouhsari Ebrahim, Gheysarzadeh Ali , Maleki Abbas, Valadbeigi Hassan and Sadeghifard Nourkhoda *, The Prevalence of Shiga Toxin-1 in Non-Shigella Dysenteriae Isolates Collected from Diarrhea Samples in Patients, Ahvaz, Iran, Infectious Disorders - Drug Targets 2021; 21 (5) : e270421188775 . https://dx.doi.org/10.2174/1871526520666201207122924

DOI https://dx.doi.org/10.2174/1871526520666201207122924	Print ISSN 1871-5265
Publisher Name Bentham Science Publisher	Online ISSN 2212-3989