Abstract
Accurate identification of infection in diabetic foot lesions is essential as the alternative can result in complicated medical and/or surgical interventions. The aim should be the differentiation between colonization and infection to avoid premature initiation of antimicrobial therapy. Diabetic foot ulcers provide a suitable environment for a diversity of microorganisms to first contaminate then subsequently colonize the wound. Infection can occur when a pathogenic factor produced by one or more microorganisms exceeds the capacity of the host immune system causing tissue damageand triggering both local and systemic inflammatory responses. The progression from wound colonization to infection is influenced by various factors including type and depth of the wound, blood supply, immune status of the patient. The quantity of microbial flora and pathogenicity expressed by the microorganisms involved will also have an effect.
Keywords: Ulceration, Infection, Colonisation, Contamination, Microorganisms
Current Diabetes Reviews
Title:Opportunistic Pathogens in Diabetic Foot Lesions
Volume: 8 Issue: 3
Author(s): Frank L. Bowling, Sanjay U. Dissanayake and Edward B. Jude
Affiliation:
Keywords: Ulceration, Infection, Colonisation, Contamination, Microorganisms
Abstract: Accurate identification of infection in diabetic foot lesions is essential as the alternative can result in complicated medical and/or surgical interventions. The aim should be the differentiation between colonization and infection to avoid premature initiation of antimicrobial therapy. Diabetic foot ulcers provide a suitable environment for a diversity of microorganisms to first contaminate then subsequently colonize the wound. Infection can occur when a pathogenic factor produced by one or more microorganisms exceeds the capacity of the host immune system causing tissue damageand triggering both local and systemic inflammatory responses. The progression from wound colonization to infection is influenced by various factors including type and depth of the wound, blood supply, immune status of the patient. The quantity of microbial flora and pathogenicity expressed by the microorganisms involved will also have an effect.
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Cite this article as:
L. Bowling Frank, U. Dissanayake Sanjay and B. Jude Edward, Opportunistic Pathogens in Diabetic Foot Lesions, Current Diabetes Reviews 2012; 8 (3) . https://dx.doi.org/10.2174/157339912800563990
DOI https://dx.doi.org/10.2174/157339912800563990 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
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