Abstract
Hypoxia-ischemia is responsible for a high morbidity and mortality rate, both in infant and adult patients. In humans, the brain is immature from fetal to postnatal life, demonstrating more specific vulnerability than the adult one, induced by exposure at perinatal asphyxia. The extension and distribution of brain lesions depend to a large extent on the intensity and exposure to injury, the maturational stage, the affected brain region and the survival time of the patient. Different cellular events are developed in response to hypoxic-ischemic injury. These events have been related to the excitotoxicity (activation of glutamate receptors), energy failure (decrease in ATP levels), inflammatory cascade (delivery of inflammatory mediators), and gene and transcriptional activation.
Keywords: Hipoxia-Ischemia, Perinatal asphyxia, Brain damage, Excitotoxicity
Current Pediatric Reviews
Title: Cellular Mechanisms in Perinatal Hypoxic-Ischemic Brain Injury
Volume: 2 Issue: 2
Author(s): Enrique Hilario, Antonia Alvarez, Francisco J. Alvarez, Elena Gastiasoro and Adolf Valls-i-Soler
Affiliation:
Keywords: Hipoxia-Ischemia, Perinatal asphyxia, Brain damage, Excitotoxicity
Abstract: Hypoxia-ischemia is responsible for a high morbidity and mortality rate, both in infant and adult patients. In humans, the brain is immature from fetal to postnatal life, demonstrating more specific vulnerability than the adult one, induced by exposure at perinatal asphyxia. The extension and distribution of brain lesions depend to a large extent on the intensity and exposure to injury, the maturational stage, the affected brain region and the survival time of the patient. Different cellular events are developed in response to hypoxic-ischemic injury. These events have been related to the excitotoxicity (activation of glutamate receptors), energy failure (decrease in ATP levels), inflammatory cascade (delivery of inflammatory mediators), and gene and transcriptional activation.
Export Options
About this article
Cite this article as:
Hilario Enrique, Alvarez Antonia, Alvarez J. Francisco, Gastiasoro Elena and Valls-i-Soler Adolf, Cellular Mechanisms in Perinatal Hypoxic-Ischemic Brain Injury, Current Pediatric Reviews 2006; 2 (2) . https://dx.doi.org/10.2174/157339606776894667
DOI https://dx.doi.org/10.2174/157339606776894667 |
Print ISSN 1573-3963 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6336 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Pentacyclic Triterpenoids in Herbal Medicines and Their Pharmacological Activities in Diabetes and Diabetic Complications
Current Medicinal Chemistry Photothermal Therapy: A New Approach to Eradicate Cancer
Current Nanoscience Current Challenges and Future of Lipid Nanoparticles Formulations for Topical Drug Application to Oral Mucosa, Skin, and Eye
Current Pharmaceutical Design Editorial: Targeting Cerebral Vascular Injury for Intervention
Current Drug Delivery A New Combined Therapeutic Strategy of Governor Vessel Electro-Acupuncture and Adult Stem Cell Transplantation Promotes the Recovery of Injured Spinal Cord
Current Medicinal Chemistry A Systematic Approach to Hypertensive Urgencies and Emergencies
Current Hypertension Reviews Meet Our Editorial Board Member
Recent Patents on Anti-Infective Drug Discovery Magnetic Resonance Imaging of the Preterm Infant Brain
Current Pediatric Reviews Withdrawal Notice: A Panoramic View on the Phytochemical, Nutritional and Therapeutic value of Ziziphus mauritiana Lam.: A Comprehensive Review
Mini-Reviews in Medicinal Chemistry Challenges in the Correct Assessment of a Case of Aggressive Thyroid Carcinoma with Synchronous Breast Cancer: A Case Report and Review of the Literature of Essential Role of Radiopharmaceuticals
Current Radiopharmaceuticals Editorial
Recent Patents on Drug Delivery & Formulation Sleep and the Immune System
Current Immunology Reviews (Discontinued) Nitric Oxide Production during Cerebral Ischemia and Reperfusion in eNOS- and nNOS-Knockout Mice
Current Neurovascular Research Antisense Oligonucleotides in the Treatment of Cerebral Gliomas. Review of Concerning Patents
Recent Patents on CNS Drug Discovery (Discontinued) Advanced Nanomedicines for the Treatment and Diagnosis of Myocardial Infarction and Heart Failure
Current Drug Targets Endocannabinoids in Liver Disease and Hepatic Encephalopathy
Current Pharmaceutical Design Biomarkers in the Diagnosis of Ventilator-Associated Pneumonia
Current Respiratory Medicine Reviews Current Pharmaceutical Design on Adhesive Based Transdermal Drug Delivery Systems
Current Pharmaceutical Design Stem Cell Behavior at Hypothermia: A Review Article
Current Stem Cell Research & Therapy Anaemia in Diabetes: An Emerging Complication of Microvascular Disease
Current Diabetes Reviews