Abstract
Eosinophilic esophagitis (EoE) is a disease based on a clinico-pathologic diagnosis which involves a localized eosinophilic inflammation of the esophagus. There has been a significant increase in the incidence of diagnosis of pediatric EoE over the past 10 years due, in part, to a greater recognition of the disease among gastroenterologists, allergists and pathologists. EoE is defined by the presence of 15 or more eosinophils per high-powered field on esophagastroduodenoscopic biopsies isolated to the esophagus associated with characteristic clinical symptoms which do not respond to gastric acid-blockade. While the exact mechanism of EoE is unknown, food allergens are thought to play a significant role. When available, a combination of skin prick and atopy patch testing may be useful when attempting to identify IgE and non-IgE based food allergens in patients with EoE. Effective treatment options include dietary restrictions and various steroid formulations. A multidisciplinary approach is essential for a timely diagnosis and successful treatment strategies in patients with EoE.
Keywords: Eosinophilic esophagitis, EoE
Current Pediatric Reviews
Title: Pediatric Eosinophilic Esophagitis: Epidemiology, Diagnosis and Treatment
Volume: 4 Issue: 4
Author(s): James P. Franciosi, Terri Brown-Whitehorn and Chris A. Liacouras
Affiliation:
Keywords: Eosinophilic esophagitis, EoE
Abstract: Eosinophilic esophagitis (EoE) is a disease based on a clinico-pathologic diagnosis which involves a localized eosinophilic inflammation of the esophagus. There has been a significant increase in the incidence of diagnosis of pediatric EoE over the past 10 years due, in part, to a greater recognition of the disease among gastroenterologists, allergists and pathologists. EoE is defined by the presence of 15 or more eosinophils per high-powered field on esophagastroduodenoscopic biopsies isolated to the esophagus associated with characteristic clinical symptoms which do not respond to gastric acid-blockade. While the exact mechanism of EoE is unknown, food allergens are thought to play a significant role. When available, a combination of skin prick and atopy patch testing may be useful when attempting to identify IgE and non-IgE based food allergens in patients with EoE. Effective treatment options include dietary restrictions and various steroid formulations. A multidisciplinary approach is essential for a timely diagnosis and successful treatment strategies in patients with EoE.
Export Options
About this article
Cite this article as:
Franciosi P. James, Brown-Whitehorn Terri and Liacouras A. Chris, Pediatric Eosinophilic Esophagitis: Epidemiology, Diagnosis and Treatment, Current Pediatric Reviews 2008; 4 (4) . https://dx.doi.org/10.2174/157339608787407645
DOI https://dx.doi.org/10.2174/157339608787407645 |
Print ISSN 1573-3963 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6336 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Role of the Thrombospondins in Healing Myocardial Infarcts
Cardiovascular & Hematological Agents in Medicinal Chemistry Recent Advances in the Development of Novel Therapeutics Targeting Dendritic Cells
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Subject index to volume 3
Current Molecular Medicine Main Analytical Methods for the Viability Assessment of Mesenchymal Stem Cells for Use as Cellular Medicines
Current Pharmaceutical Analysis Notch Signaling in Cardiovascular Disease and Calcification
Current Cardiology Reviews Antileukotriene Drugs: Clinical Application, Effectiveness and Safety
Current Medicinal Chemistry Role of Acetylcholinesterase Inhibitors in the Metabolism of Amyloid Precursor Protein
Current Drug Targets - CNS & Neurological Disorders Lipopolysaccharide-Induced Chorioamnionitis Causes Acute Inflammatory Changes in the Ovine Central Nervous System
CNS & Neurological Disorders - Drug Targets Marine Bioactive Peptides as Potential Antioxidants
Current Protein & Peptide Science Viral Vectors for Gene-Directed Enzyme Prodrug Therapy
Current Gene Therapy Macrogols: A Misleading Cause of Drug Hypersensitivity Diagnosis
Clinical Immunology, Endocrine & Metabolic Drugs (Discontinued) Using Literature-based Discovery to Identify Novel Therapeutic Approaches
Cardiovascular & Hematological Agents in Medicinal Chemistry Phospholipid/Bile Salt Based Novel Mixed Nanomicelles of Methotrexate Co-encapsulated with Sesamol: Preparation, Characterization, and Evaluation of Antiradical Effects In Vitro
Current Nanomedicine Treatment Strategies for Multiple Myeloma in the Age of Novel Therapies
Current Cancer Therapy Reviews Recent Developments in Patents Targeting Toll-Like Receptor Genes
Recent Patents on DNA & Gene Sequences Purine Ionotropic (P2X) Receptors
Current Pharmaceutical Design Predicting Pediatric Drug Disposition-Present and Future Directions of Pediatric Physiologically-Based Pharmacokinetics
Drug Metabolism Letters Chemopreventive Effects of Conjugated Linolenic Acids (CLN) Occurring in Plant Seed Oils
Current Nutrition & Food Science Flavonoid-Based Cancer Therapy: An Updated Review
Anti-Cancer Agents in Medicinal Chemistry Mechanistic Considerations on the Development of Lung Edema: Vascular, Perivascular and Molecular Aspects from Early Stage to Tissue and Vascular Remodeling Stage
Current Respiratory Medicine Reviews