Abstract
Cell movement and adhesion serve critical roles in a wide variety of physiological situations, and when dysregulated can contribute to the pathogenesis of many diseases. Recently, Lyn kinase has emerged as a crucial regulator of ‘inside-out’ integrin signaling in hematopoietic cells, that when dysregulated, can lead to the development of an “invasive cell” phenotype in a variety of pathological contexts ranging from leukemia to neuro-inflammatory disorders. Here, we discuss several pathologies associated with perturbations of Lyn-dependent inside-out integrin signaling pathways in blood cells.
Current Signal Transduction Therapy
Title: The Novel Role for Lyn in Integrin Signaling in Human Disease
Volume: 4 Issue: 1
Author(s): Brian Tomkowicz and Andrzej Ptasznik
Affiliation:
Abstract: Cell movement and adhesion serve critical roles in a wide variety of physiological situations, and when dysregulated can contribute to the pathogenesis of many diseases. Recently, Lyn kinase has emerged as a crucial regulator of ‘inside-out’ integrin signaling in hematopoietic cells, that when dysregulated, can lead to the development of an “invasive cell” phenotype in a variety of pathological contexts ranging from leukemia to neuro-inflammatory disorders. Here, we discuss several pathologies associated with perturbations of Lyn-dependent inside-out integrin signaling pathways in blood cells.
Export Options
About this article
Cite this article as:
Tomkowicz Brian and Ptasznik Andrzej, The Novel Role for Lyn in Integrin Signaling in Human Disease, Current Signal Transduction Therapy 2009; 4 (1) . https://dx.doi.org/10.2174/157436209787048685
DOI https://dx.doi.org/10.2174/157436209787048685 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Role of the Tyrosine Kinase Inhibitor STI571 in the Treatment of Cancer
Current Cancer Drug Targets The Functions of Histone Modification Enzymes in Cancer
Current Protein & Peptide Science Ceramidases in Hematological Malignancies: Senseless or Neglected Target?
Anti-Cancer Agents in Medicinal Chemistry Regulatory Overview of Biosimilars: Current Scenario and Future Opportunities
Applied Clinical Research, Clinical Trials and Regulatory Affairs Agonists and Antagonists Acting at P2X7 Receptor
Current Topics in Medicinal Chemistry Gene Therapy for Haemophagocytic Lymphohistiocytosis
Current Gene Therapy Cancer Stem Cells: The Emerging Challenge of Drug Targeting
Current Medicinal Chemistry Alkylating Agents, the Road Less Traversed, Changing Anticancer Therapy
Anti-Cancer Agents in Medicinal Chemistry Bombacaceae Between the Ethnomedical Uses and Pharmacological Evidences: A Review
The Natural Products Journal Multi-Nuclear Platinum Drugs: A New Paradigm in Chemotherapy
Current Medicinal Chemistry - Anti-Cancer Agents Emerging Indications for Statins: A Pluripotent Family of Agents with Several Potential Applications
Current Pharmaceutical Design Sphere Formation Assay is not an Effective Method for Cancer Stem Cell Derivation and Characterization from the Caco-2 Colorectal Cell Line
Current Stem Cell Research & Therapy Cancer Stem Cells and the Tumor Microenvironment: Soloists or Choral Singers
Current Pharmaceutical Biotechnology Relevance of the Deletion Polymorphisms of the Glutathione S-Transferases GSTT1 and GSTM1 in Pharmacology and Toxicology
Current Drug Metabolism Melittin: A Natural Peptide with Expanded Therapeutic Applications
The Natural Products Journal Retroviral Gene Therapy: Safety Issues and Possible Solutions
Current Gene Therapy Biologics for ANCA-Associated Vasculitis
Inflammation & Allergy - Drug Targets (Discontinued) Differentiation Potential of Human Retinoblastoma Cells
Current Pharmaceutical Biotechnology Biomarkers of Protein Oxidation in Human Disease
Current Molecular Medicine Bladder Cancer: A Simple Model Becomes Complex
Current Genomics