Abstract
The 9-aminoacridines play an important role in medicine. They were applied first in a treatment of protozoal infections in the beginning of the last century. Recently, it has been shown that the 9-aminoacridines are successful candidates for treatment of cancer, viral and prion diseases. Their conjugation with biomolecules such as peptides and proteins may modulate their activity, bioavailability and applicability. This review deals with the synthesis of 9-aminoacridine, its conjugation with variety of molecules and utilization of such conjugates in several fields of science.
Keywords: Acridines, 9-aminoacridine, conjugates, nucleic acids, proteins
Current Protein & Peptide Science
Title: A Role of the 9-Aminoacridines and their Conjugates in a Life Science
Volume: 8 Issue: 5
Author(s): Jaroslav Sebestik, Jan Hlavacek and Ivan Stibor
Affiliation:
Keywords: Acridines, 9-aminoacridine, conjugates, nucleic acids, proteins
Abstract: The 9-aminoacridines play an important role in medicine. They were applied first in a treatment of protozoal infections in the beginning of the last century. Recently, it has been shown that the 9-aminoacridines are successful candidates for treatment of cancer, viral and prion diseases. Their conjugation with biomolecules such as peptides and proteins may modulate their activity, bioavailability and applicability. This review deals with the synthesis of 9-aminoacridine, its conjugation with variety of molecules and utilization of such conjugates in several fields of science.
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Cite this article as:
Sebestik Jaroslav, Hlavacek Jan and Stibor Ivan, A Role of the 9-Aminoacridines and their Conjugates in a Life Science, Current Protein & Peptide Science 2007; 8 (5) . https://dx.doi.org/10.2174/138920307782411400
DOI https://dx.doi.org/10.2174/138920307782411400 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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