Interaction of EGLIN C Variants with the Extended Subsites of the Precursor Processing Proteases*.

Title: Interaction of EGLIN C Variants with the Extended Subsites of the Precursor Processing Proteases*.

Volume: 12 Issue: 5

Author(s): Tomoko Komiyama

Affiliation:

Keywords: furin, kex, pc, binding sites, eglin c

Abstract: Potent inhibitors of the Kex2/furin family precursor processing proteases were developed by randomizing adventitious contact sites and screening for optimized affinity using inhibition assays in 96-well format [1]. In this review, the binding interactions of the developed inhibitors will be examined in light of the three dimensional structures of Kex2 and furin [2-4].

Cite this article as:

Komiyama Tomoko, Interaction of EGLIN C Variants with the Extended Subsites of the Precursor Processing Proteases*., Protein & Peptide Letters 2005; 12 (5) . https://dx.doi.org/10.2174/0929866054395220