Abstract
The mannose receptor (MR) recognizes a range of carbohydrates present on the surface and cell walls of micro-organisms. The MR is primarily expressed on macrophages and dendritic cells and is involved in MR-mediated endocytosis and phagocytosis. In addition, the MR plays a key role in host defense and provides a link between innate and adaptive immunity. Herein, we will review the role of the MR in innate host defense as well as the recent evidence for its role in the adaptive response, for both humoral and cellular immune responses.
Keywords: Mannose Receptor, Immune Response, mannose receptor (MR), DRUG THERAPY
Current Molecular Medicine
Title: Role of the Mannose Receptor in the Immune Response
Volume: 1 Issue: 4
Author(s): V. Apostolopoulos and I. f.c. Mckenzie
Affiliation:
Keywords: Mannose Receptor, Immune Response, mannose receptor (MR), DRUG THERAPY
Abstract: The mannose receptor (MR) recognizes a range of carbohydrates present on the surface and cell walls of micro-organisms. The MR is primarily expressed on macrophages and dendritic cells and is involved in MR-mediated endocytosis and phagocytosis. In addition, the MR plays a key role in host defense and provides a link between innate and adaptive immunity. Herein, we will review the role of the MR in innate host defense as well as the recent evidence for its role in the adaptive response, for both humoral and cellular immune responses.
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Cite this article as:
Apostolopoulos V. and Mckenzie f.c. I., Role of the Mannose Receptor in the Immune Response, Current Molecular Medicine 2001; 1 (4) . https://dx.doi.org/10.2174/1566524013363645
DOI https://dx.doi.org/10.2174/1566524013363645 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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