Abstract
The survival of children with cancer has improved dramatically in the last decades. Survivors of childhood cancer are at increased risk of long-term complications of therapeutic exposure. Second malignant neoplasms are one of the most severe side effects of cancer treatment. The frequency and type of secondary cancers may vary depending on the initial diagnosis, treatment administered and genetic predisposition. This review highlights the risk factors in the development of SMNs in survivors of pediatric cancers and their differences according to primary cancer type, genetic predisposition and treatment admistered. Finally, the review emphasizes the need for life-time follow-up of survivors of childhood cancer for the development of second malignancies.
Keywords: Cancer, children, chemotherapy, radiotherapy, secondary malignant neoplasms.
Current Pediatric Reviews
Title:Secondary Neoplasms in Children Treated for Cancer
Volume: 13 Issue: 1
Author(s): Rejin Kebudi*Gul Nihal Ozdemir
Affiliation:
- Istanbul University, Cerrahpasa Medical Faculty & Oncology Institute, Pediatric Hematology- Oncology Dept., Istanbul,Turkey
Keywords: Cancer, children, chemotherapy, radiotherapy, secondary malignant neoplasms.
Abstract: The survival of children with cancer has improved dramatically in the last decades. Survivors of childhood cancer are at increased risk of long-term complications of therapeutic exposure. Second malignant neoplasms are one of the most severe side effects of cancer treatment. The frequency and type of secondary cancers may vary depending on the initial diagnosis, treatment administered and genetic predisposition. This review highlights the risk factors in the development of SMNs in survivors of pediatric cancers and their differences according to primary cancer type, genetic predisposition and treatment admistered. Finally, the review emphasizes the need for life-time follow-up of survivors of childhood cancer for the development of second malignancies.
Export Options
About this article
Cite this article as:
Kebudi Rejin*, Ozdemir Nihal Gul, Secondary Neoplasms in Children Treated for Cancer, Current Pediatric Reviews 2017; 13 (1) . https://dx.doi.org/10.2174/1573396313666161114233135
DOI https://dx.doi.org/10.2174/1573396313666161114233135 |
Print ISSN 1573-3963 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6336 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Anticipation in Lynch Syndrome: Where We Are Where We Go
Current Genomics Anti-Cancer Compounds Targeted to VDAC: Potential and Perspectives
Current Medicinal Chemistry Heart Failure in Sub-Saharan Africa
Current Cardiology Reviews The Early Bird Catches the Worm – Can Evolution Teach us Lessons in Fighting HIV?
Current HIV Research Cysteinyl Leukotrienes (CysLTs): Role in Obesity-Induced Asthma
Current Molecular Medicine Renin Angiotensin System (RAS) and Immune System Profile in Specific Subgroups with COVID-19
Current Medicinal Chemistry OX40 and OX40L Interaction in Cancer
Current Medicinal Chemistry Main Nutritional and Environmental Risk Factors in Children with Leukemia from a Public Hospital of the State of Guanajuato, Mexico
Current Cancer Therapy Reviews Pharmacogenomics: The Influence of Genomic Variation on Drug Response
Current Topics in Medicinal Chemistry The Many Faces of Glutathione Transferase Pi
Current Molecular Medicine Targeting of Hsp32 in Solid Tumors and Leukemias: A Novel Approach to Optimize Anticancer Therapy (Supplementry Material)
Current Cancer Drug Targets Disorders of Protein Biogenesis and Stability
Protein & Peptide Letters Human Carbonyl Reductases
Current Drug Metabolism Perinatal Management of Fetal Tumors
Current Pediatric Reviews Epigenetics, Depression and Antidepressant Treatment
Current Pharmaceutical Design Synthetic Approaches to Various Class of Topoisomerase II Inhibitors
Mini-Reviews in Organic Chemistry Stem Cell Transplantation and MBL Replacement Therapy
Current Stem Cell Research & Therapy The Emerging Role of Unmetabolized Folic Acid in Human Diseases: Myth or Reality?
Current Drug Metabolism Targeting c-MET/HGF Signaling Pathway in Upper Gastrointestinal Cancers: Rationale and Progress
Current Drug Targets Fibromyalgia and Bipolar Disorder: Emerging Epidemiological Associations and Shared Pathophysiology
Current Molecular Medicine