Abstract
The relatively simple peptides assembled on the templates are excellent mimic of complex conformational and functional defined binding sites of proteins. The main benefit of experiments with artificial receptors arises from the relative simplicity of the interacting host-guest system allowing the understanding of the rules controlling the model process of the molecular recognition. Efficient modification of molecular receptors by using rational design of their structure or combinatorial methods is crucial for verification of any hypothesis concerning the binding forces or enhancing the binding properties. This approach is presenting promising strategy for understanding mode of action and the control of biological functions of proteins, for designing new pharmaceutically active compounds, new tools for medical diagnostic and molecular sensing.
Keywords: artificial protein mimics, cellulose, combinatorial chemistry, molecular receptor, protein binding, host-guest interactions.
Current Protein & Peptide Science
Title:Cellulose Template Assembled Synthetic Peptides as Molecular Receptors
Volume: 17 Issue: 2
Author(s): Justyna Frączyk, Małgorzata Walczak and Zbigniew J. Kamiński
Affiliation:
Keywords: artificial protein mimics, cellulose, combinatorial chemistry, molecular receptor, protein binding, host-guest interactions.
Abstract: The relatively simple peptides assembled on the templates are excellent mimic of complex conformational and functional defined binding sites of proteins. The main benefit of experiments with artificial receptors arises from the relative simplicity of the interacting host-guest system allowing the understanding of the rules controlling the model process of the molecular recognition. Efficient modification of molecular receptors by using rational design of their structure or combinatorial methods is crucial for verification of any hypothesis concerning the binding forces or enhancing the binding properties. This approach is presenting promising strategy for understanding mode of action and the control of biological functions of proteins, for designing new pharmaceutically active compounds, new tools for medical diagnostic and molecular sensing.
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Cite this article as:
Frączyk Justyna, Walczak Małgorzata and Kamiński J. Zbigniew, Cellulose Template Assembled Synthetic Peptides as Molecular Receptors, Current Protein & Peptide Science 2016; 17 (2) . https://dx.doi.org/10.2174/138920371702160209122710
DOI https://dx.doi.org/10.2174/138920371702160209122710 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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