Abstract
Chemical investigation of the endophytic strain A1021B ascribed to the Fusarium incarnatum-equiseti species complex led to the isolation of a novel pyridine alkaloid related to fusaric acid. The structure was elucidated by 1D and 2D NMR experiments (1H, 13C, COSY, HSQC, CIGAR-HMBC, H2BC). The compound induced cytotoxic effects on six human cancer cell lines (SK-N-BE(2)-C, SH-SY5Y, A549, HepG2, HeLa, and MCF-7).
Keywords: Cytotoxicity, endophyte, fusarinol, Fusarium incarnatum-equiseti, NMR analysis.
Current Bioactive Compounds
Title:Spectroscopic Characterization of a Pyridine Alkaloid from an Endophytic Strain of the Fusarium incarnatum-equiseti Species Complex
Volume: 10 Issue: 3
Author(s): Monica Scognamiglio, Rosario Nicoletti, Severina Pacifico, Brigida D'Abrosca and Antonio Fiorentino
Affiliation:
Keywords: Cytotoxicity, endophyte, fusarinol, Fusarium incarnatum-equiseti, NMR analysis.
Abstract: Chemical investigation of the endophytic strain A1021B ascribed to the Fusarium incarnatum-equiseti species complex led to the isolation of a novel pyridine alkaloid related to fusaric acid. The structure was elucidated by 1D and 2D NMR experiments (1H, 13C, COSY, HSQC, CIGAR-HMBC, H2BC). The compound induced cytotoxic effects on six human cancer cell lines (SK-N-BE(2)-C, SH-SY5Y, A549, HepG2, HeLa, and MCF-7).
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Scognamiglio Monica, Nicoletti Rosario, Pacifico Severina, D'Abrosca Brigida and Fiorentino Antonio, Spectroscopic Characterization of a Pyridine Alkaloid from an Endophytic Strain of the Fusarium incarnatum-equiseti Species Complex, Current Bioactive Compounds 2014; 10 (3) . https://dx.doi.org/10.2174/1573407210666140716163923
DOI https://dx.doi.org/10.2174/1573407210666140716163923 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
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