摘要
目的:研究表明最小干扰对轻度阿尔茨海默病(AD)患者的项目记忆有良好的影响。我们进行了一项研究,以测试这些有益的影响是否延伸到源头。 记忆,即记忆以前获得信息的情景的能力。 方法:26名轻度AD参与者和28名对照者操纵6个对象或观察实验者操纵其他6个对象。立即召回物品后(什么是商品?)和苏。 RCE召回(以前是由谁操纵的),干扰或最小干扰条件被管理。在干扰情况下,参与者使用neu进行评估。 心理测试10分钟。在最小干扰的情况下,他们独自在一个黑暗和安静的房间休息10分钟。同时遵循干扰和最小干扰条件。 通过延迟回忆,参与者被要求记住先前呈现的对象及其来源。 结果:轻度干扰组的项目记忆高于AD组(p<.01)和对照组(p<.01)。此外,AD参与者展示了更高的项目。 即刻回忆时的记忆比后续干扰(p<.001)或最小干扰(p<.001);控制组在立即回忆时的项目记忆也比后续干扰更高(p<.001)。 .001)或最小干扰(p<.001)。考虑到源记忆,AD参与者(p>1)和对照组(p>1)在干扰和最小干扰后有相似的源记忆(P>0.05)。 1)此外,AD参与者在立即回忆时比干扰(p<.001)或最小干扰(p<.001)表现出更高的源记忆;对照组也显示出更高的源备忘录 立即回忆比跟随干扰(p<.001)或最小干扰(p<.001)。 结论:AD患者海马依赖的联想或巩固过程的失败可能排除了对源记忆干扰最小的好处。然而,AD患者可能会显示出一些Capa。 城市要保留简单的材料,如果材料呈现后有短时间的延迟,就没有进一步的刺激。
关键词: 阿尔茨海默病,海马,记忆康复,最小干扰,源记忆。
Current Alzheimer Research
Title:Beneficial effect of minimal interference on item memory but not on source memory in Alzheimer's disease
Volume: 15 Issue: 11
关键词: 阿尔茨海默病,海马,记忆康复,最小干扰,源记忆。
摘要: Objectives: Research suggests beneficial effects of minimal interference on item memory in mild Alzheimer’s disease (AD). We conducted a study to test whether these beneficial effects extend to source memory, i.e., the ability to remember the episodic context in which an information was previously acquired.
Method: Twenty-six mild AD participants and 28 controls manipulated six objects or watched the experimenter manipulating six other objects. After immediate item recall (“what were the items?”) and source recall (“by whom the items were previously manipulated?”), an interference or a minimal interference condition was administrated. In the interference condition, participants were assessed with neuropsychological tests for 10 min. In the minimal interference condition, they rested alone in a dark and quiet room for 10 minutes. Both interference and minimal interference conditions were followed by the delayed recall, on which participants were asked to remember the previously-presented objects and their source.
Results: Higher item memory was observed following minimal interference than following interference in AD participants (p < .01) and controls (p < .01). Also, AD participants demonstrated higher item memory on immediate recall than following interference (p < .001) or minimal interference (p < .001); controls also demonstrated higher item memory on immediate recall than following interference (p < .001) or minimal interference (p < .001). Considering source memory, similar source memory was observed following interference and minimal interference in AD participants (p > .1) and controls (p > .1). Also, AD participants demonstrated higher source memory on immediate recall than following interference (p < .001) or minimal interference (p < .001); controls also demonstrated higher source memory on immediate recall than following interference (p < .001) or minimal interference (p < .001).
Conclusion: Failures of hippocampus-dependent associative or consolidation processes in AD may preclude benefits of minimal interference for source memory. Nevertheless, AD patients may show some capacity to retain simple material, should the material presentation be followed by short delays that are free of further stimuli.
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Cite this article as:
Beneficial effect of minimal interference on item memory but not on source memory in Alzheimer's disease, Current Alzheimer Research 2018; 15 (11) . https://dx.doi.org/10.2174/1567205015666180711105242
DOI https://dx.doi.org/10.2174/1567205015666180711105242 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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Aims and Scope: Introduction: Alzheimer's disease (AD) poses a significant global health challenge, with an increasing prevalence that demands concerted efforts to advance our understanding and strategies for prevention, diagnosis, treatment, and rehabilitation. This thematic issue aims to bring together cutting-edge research and innovative approaches from multidisciplinary perspectives to address ...read more
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Current updates on the Role of Neuroinflammation in Neurodegenerative Disorders
Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
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Alzheimer's disease (AD) poses a significant global health challenge, with an increasing number of individuals affected yearly. Deep learning, a subfield of artificial intelligence, has shown immense potential in various domains, including healthcare. This thematic issue of Current Alzheimer Research explores the application of deep learning techniques in advancing our ...read more
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