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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

The Several Activities of 4 - Methyl Pyrazole in Animals and Humans

Author(s): Gaetano Iaquinto*

Volume 24 , Issue 18 , 2018

Page: [1957 - 1960] Pages: 4

DOI: 10.2174/1381612824666180529081328

Price: $65

Abstract

4-MP is a potent competitive inhibitor of ADH activity with an affinity about a 1000 times more than toxic alcohols. 4-MP was shown to reduce the formation of toxic metabolites in lethal methanol and ethylene glycol poisoning in animal models and in methanol poisoning in humans. 4-MP has long-lasting gastroprotective effect against ethanol and other chemically induced acute gastric mucosa lesions in rats. We showed, for the first time, that 4-MP also provides significant protection of the human stomach against alcohol induced acute mucosal injury.

Keywords: 4 methyl pyrazole, alchol gastric, mucosal injury, gastroprotection, ADH, ethanol, alcohol.


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