Why Methylene Blue Have to Be Always Present in the Stocking of Emergency Antidotes

Title:Why Methylene Blue Have to Be Always Present in the Stocking of Emergency Antidotes

Volume: 19 Issue: 13

Author(s): Caroline F. Baldo, Luiza M. Silva, Livia Arcencio, Agnes A.S. Albuquerque, Andrea C. Celotto, Anibal Basile-Filho and Paulo R.B. Evora*

Affiliation:

• Department of Surgery and Anatomy, Ribeirao Preto School of Medicine, University of Sao Paulo, SP,Brazil

Keywords: Methylene blue, cGMP, nitric oxide, circulatory shock, neuroprotection, anaphylaxis, poisoning.

Abstract: Evidence-based review of the existing literature ultimately recommends stocking of Methylene Blue (MB) as an emergency antidote in the United States. The same is reported around the world in Japan, Greece, Italy and Canada. The observation that MB is always present as the main antidote required in emergency and critical care units calls for a revisit on its effects on the NO/cGMP system to reemphasize its multisystem actions. Therefore, the present review aimed to display the role of MB in emergency units, concerning: 1) Polytrauma and circulatory shock; 2) Neuroprotection, 3) Anaphylaxis and, 4) Overdose and poisoning.

Cite this article as:

Baldo F. Caroline, Silva M. Luiza, Arcencio Livia, Albuquerque A.S. Agnes, Celotto C. Andrea, Basile-Filho Anibal and Evora R.B. Paulo*, Why Methylene Blue Have to Be Always Present in the Stocking of Emergency Antidotes, Current Drug Targets 2018; 19(13) . https://dx.doi.org/10.2174/1389450119666180403100410