Review Article

Why Methylene Blue Have to Be Always Present in the Stocking of Emergency Antidotes

Author(s): Caroline F. Baldo, Luiza M. Silva, Livia Arcencio, Agnes A.S. Albuquerque, Andrea C. Celotto, Anibal Basile-Filho and Paulo R.B. Evora*

Volume 19, Issue 13, 2018

Page: [1550 - 1559] Pages: 10

DOI: 10.2174/1389450119666180403100410

Price: $65

Abstract

Evidence-based review of the existing literature ultimately recommends stocking of Methylene Blue (MB) as an emergency antidote in the United States. The same is reported around the world in Japan, Greece, Italy and Canada. The observation that MB is always present as the main antidote required in emergency and critical care units calls for a revisit on its effects on the NO/cGMP system to reemphasize its multisystem actions. Therefore, the present review aimed to display the role of MB in emergency units, concerning: 1) Polytrauma and circulatory shock; 2) Neuroprotection, 3) Anaphylaxis and, 4) Overdose and poisoning.

Keywords: Methylene blue, cGMP, nitric oxide, circulatory shock, neuroprotection, anaphylaxis, poisoning.

Graphical Abstract

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